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CD86 [plasma membrane]
Stable Identifier
R-HSA-179784
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
CD86 monomer
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
PI3K binds CD28 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
CD28 dependent Vav1 pathway (Homo sapiens)
Activation of Cdc42 by pVav1 (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
Activation of Rac1 by pVav1 (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
Activation of Vav1 (Homo sapiens)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
Grb2 binds CD28 (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
Translocation of Vav1 to CD28 (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
CD28 homodimer binds B7-2 monomer (Homo sapiens)
CD28:B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
Gads binds CD28 (Homo sapiens)
CD28:GRAP2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
Phosphorylation of CD28 (Homo sapiens)
CD28:B7-1,B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
CTLA4 inhibitory signaling (Homo sapiens)
CTLA-4 binds B7-1/B7-2 (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
Phosphorylation of CTLA-4 (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Homo sapiens)
p-Y201,Y218-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
SHP2 phosphatase binds CTLA-4 (Homo sapiens)
p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Homo sapiens)
p-Y201,Y218-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Homo sapiens)
p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Homo sapiens)
p-Y201,Y218-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 negatively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)
IL10-downregulated plasma membrane proteins [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD86 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42081 CD86
Gene Names
CD86, CD28LG2
Chain
signal peptide:1-23, chain:24-329
Reference Genes
BioGPS Gene:942 CD86
COSMIC (genes):CD86 CD86
CTD Gene:942 CD86
dbSNP Gene:942 CD86
ENSEMBL:ENSG00000114013 CD86
ENSEMBL_homo_sapiens_GENE:ENSG00000114013.16 CD86
HGNC:1705 CD86
KEGG Gene (Homo sapiens):942 CD86
Monarch:942 CD86
NCBI Gene:942 CD86
OMIM:601020 CD86
UCSC:P42081 CD86
Reference Transcript
RefSeq:NM_001206924.1 CD86
RefSeq:NM_175862.4 CD86
RefSeq:NM_001206925.1 CD86
RefSeq:NM_176892.1 CD86
RefSeq:NM_006889.4 CD86
Other Identifiers
11724997_a_at
11724998_a_at
11736375_a_at
11746658_a_at
11751135_a_at
16944618
205685_PM_at
205685_at
205686_PM_s_at
205686_s_at
210895_PM_s_at
210895_s_at
2638790
2638797
2638798
2638801
2638809
2638810
2638815
2638820
2638821
2638822
2638823
36270_at
54585_at
7896700
7896718
8082035
942
A_14_P116067
A_14_P120633
A_23_P109988
A_24_P131589
GE58874
GO:0001618
GO:0002250
GO:0002376
GO:0002639
GO:0005515
GO:0005576
GO:0005615
GO:0005815
GO:0005856
GO:0005886
GO:0006351
GO:0006355
GO:0006955
GO:0007155
GO:0007166
GO:0007202
GO:0008284
GO:0009897
GO:0009986
GO:0015026
GO:0016020
GO:0023035
GO:0023052
GO:0030154
GO:0031295
GO:0032743
GO:0032753
GO:0032761
GO:0034451
GO:0036211
GO:0038023
GO:0042102
GO:0042110
GO:0042113
GO:0043226
GO:0045630
GO:0045893
GO:0046718
GO:0048018
GO:0048856
GO:0060089
GO:0070062
GO:0071222
GO:0098772
GO:1901224
GO:1990051
HMNXSV003050629
Hs.27954.0.S2_3p_at
ILMN_1672097
ILMN_1714602
ILMN_1782560
PH_hs_0002458
TC03000626.hg
U04343_at
g416368_3p_a_at
g5901919_3p_a_at
Participates
as a member of
IL10-downregulated plasma membrane proteins [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
as a component of
CD28:B7-2 [plasma membrane] (Homo sapiens)
as an input of
CD28 homodimer binds B7-2 monomer (Homo sapiens)
Inferred To
Cd86 [plasma membrane]
(Mus musculus)
Cd86 [plasma membrane]
(Rattus norvegicus)
CD86 [plasma membrane]
(Bos taurus)
CD86 [plasma membrane]
(Canis familiaris)
CD86 [plasma membrane]
(Gallus gallus)
CD86 [plasma membrane]
(Sus scrofa)
cd86 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_787058.4
,
NP_001193854.1
,
NP_008820.3
,
NP_795711.1
,
NP_001193853.1
Guide to Pharmacology - Targets
2745
OpenTargets
ENSG00000114013
HPA
ENSG00000114013-CD86
GeneCards
P42081
Ensembl
ENSP00000332049
,
ENST00000469710
,
ENST00000330540
,
ENSP00000418988
,
ENST00000264468
,
ENSP00000420230
,
ENSP00000377248
,
ENSG00000114013
,
ENSP00000264468
,
ENST00000393627
,
ENST00000493101
PRO
P42081
Pharos - Targets
P42081
Orphanet
25957
PDB
8HXB
,
1NCN
,
1I85
,
8HXC
,
5YXK
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P16410 CTLA4
2
p-Y201,Y218-CTLA4 [plasma membrane]
(R-HSA-388754)
CTLA4 [plasma membrane]
(R-HSA-179764)
0.692
3
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