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Pro-EGF is cleaved to form mature EGF
Stable Identifier
R-HSA-177946
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
Pro-EGF is cleaved to form mature EGF (Homo sapiens)
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Ligands of the epidermal growth factor receptor (EGFR) are shed from the plasma membrane by metalloproteases. Identification of the sheddases for EGFR ligands using mouse embryonic cells lacking candidate sheddases (a disintegrin and metalloprotease; ADAM) has revealed that ADAM10, -12 and -17 are the sheddases of the EGFR ligands in response to various shedding stimulants such as GPCR agonists, growth factors, cytokines, osmotic stress, wounding and phorbol ester. Among the EGFR ligands, heparin-binding EGF-like growth factor (HB-EGF), EGF and TGF-alpha are the best characterized.
Participants
Input
Pro-EGF [plasma membrane]
(Homo sapiens)
Output
EGF [extracellular region]
(Homo sapiens)
Participates
as an event of
Signaling by EGFR (Homo sapiens)
Catalyst Activity
metalloendopeptidase activity of ADAM:Zn2+ [plasma membrane]
Physical Entity
ADAM:Zn2+ [plasma membrane]
(Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Inferred From
Mouse pro-EGF is cleaved by ADAM sheddases (Mus musculus)
Authored
Castagnoli, L (2006-10-10)
Reviewed
Muthuswamy, S (2007-02-17)
Created
Jassal, B (2006-04-11)
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