Dephosphorylation of PAG by SHP2

Stable Identifier
R-HSA-177926
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Dephosphorylation of CBP/PAG negatively regulates the recruitment of the Src inhibiting kinase, Csk. Src is not negatively regulated by phosphorylation by Csk.

Literature References
PubMed ID Title Journal Year
14967142 Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

Zhang, SQ, Yang, W, Kontaridis, MI, Bivona, TG, Wen, G, Araki, T, Luo, J, Thompson, JA, Schraven, BL, Philips, MR, Neel, BG

Mol. Cell 2004
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created