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About
What is Reactome ?
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AP2A2(1-939) [plasma membrane]
Stable Identifier
R-HSA-177502
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Adaptor protein AP2A2
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Recycling pathway of L1 (Homo sapiens)
Formation of clathrin coated vesicle (Homo sapiens)
L1:AP-2 Clathrin complex [clathrin-coated endocytic vesicle] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
L1:clathrin-coated vesicle [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Interaction of NUMB with L1 (Homo sapiens)
CRMP-2:NUMB:alpha adaptin [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
L1:NUMB:CRMP-2:alpha-adaptin [clathrin-coated endocytic vesicle] (Homo sapiens)
CRMP-2:NUMB:alpha adaptin [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
L1 binds to AP-2 Clathrin complex (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
L1:clathrin-coated vesicle [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Phosphorylation of L1 by ERK (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
pL1 (S1204, 1248):ERK2:clathrin-dynamin complex [endosome] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Phosphorylation of L1 by p90rsk (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
pL1 (S1152):p90rsk:clathrin-dynamin complex [endosome] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Reinsertion of L1 into the plasma membrane (Homo sapiens)
AP2 clathrin:L1:KIF4:microtubule [cytosol] (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Transport of L1 from C-domain to P-domain (Homo sapiens)
AP2 clathrin:L1:KIF4:microtubule [cytosol] (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Transport of L1 into endosomes (Homo sapiens)
L1:AP-2 Clathrin complex [clathrin-coated endocytic vesicle] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)
Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Recruitment of clathrin coated vesicle by Ii (Homo sapiens)
Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule membrane proteins (Homo sapiens)
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Exocytosis of secretory granule membrane proteins (Homo sapiens)
Secretory granule membrane proteins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Retrograde neurotrophin signalling (Homo sapiens)
Axonal transport of NGF:Trk complexes (Homo sapiens)
Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex:Clathrin-coated vesicle:dynein:dynactin complex [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Endocytosis (internalization) of clathrin-coated vesicle (Homo sapiens)
Activated TrkA receptor complex:Clathrin-coated vesicle [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Formation of clathrin-coated vesicle (Homo sapiens)
Activated TrkA receptor complex:Clathrin-coated vesicle [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein clearance (Homo sapiens)
LDL clearance (Homo sapiens)
PCSK9:LDLR bind to Clathrin (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
PCSK9:LDLR:Clathrin:AP2 [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Homo sapiens)
PCSK9:LDLR:Clathrin:AP2 [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
VLDLR internalisation and degradation (Homo sapiens)
VLDLR:PCSK9 binds Clathrin-coated vesicles (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
VLDL:PCSK9:Clathrin:AP2 [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Homo sapiens)
VLDL:PCSK9:Clathrin:AP2 [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
BAR domain proteins recruit dynamin (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
Epsin family proteins bind ubiquitinated cargo (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Clathrin recruits PIK3C2A (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
Clathrin:AP-2 complex [plasma membrane] (Homo sapiens)
AP-2 complex [plasma membrane] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane] (Homo sapiens)
AP2A2(1-939) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O94973 AP2A2
Gene Names
AP2A2, ADTAB, CLAPA2, HIP9, HYPJ, KIAA0899
Chain
chain:1-939
Reference Genes
BioGPS Gene:161 AP2A2
COSMIC (genes):AP2A2 AP2A2
CTD Gene:161 AP2A2
dbSNP Gene:161 AP2A2
ENSEMBL:ENSG00000183020 AP2A2
HGNC:562 AP2A2
KEGG Gene (Homo sapiens):161 AP2A2
Monarch:161 AP2A2
NCBI Gene:161 AP2A2
OMIM:607242 AP2A2
UCSC:O94973 AP2A2
Reference Transcript
RefSeq:NM_001242837.1 AP2A2
RefSeq:NM_012305.3 AP2A2
Other Identifiers
0005340021
11741016_a_at
11741017_s_at
11755014_a_at
161
16720440
17514
211779_x_at
212159_x_at
212161_3p_at
212161_at
215764_3p_x_at
215764_x_at
32228_at
3316451
3316452
3316453
3316454
3316455
3316471
3316477
3316481
3316484
3316488
3316492
3316493
3316494
3316502
3316508
3316512
3316514
3316515
3316516
3316520
3316528
3316532
3316540
3316542
3316543
3316544
3316546
3316547
3316548
3316549
3316550
3316551
3316552
3316553
3316554
3316555
3316556
3316557
3316558
3316559
3316560
3316562
43040
7937533
A0A0G2JRS3
A_14_P126629
A_23_P21853
A_24_P339974
A_24_P932418
A_33_P3311863
AAC27505
AAH06155
AB020706
AF049527
AK027891
AK223558
AP2A2
AP2A2-201
AP2A2-202
AP2A2-213
BAA74922
BAB55435
BAD97278
BC006155
CAB017514
CCDS44512
CCDS73234
E9PNC4
E9PPY8
E9PPZ3
E9PQP4
E9PR62
E9PS94
ENSG00000183020
ENSP00000327694
ENSP00000413234
ENSP00000431630
ENST00000332231
ENST00000332231.9
ENST00000448903
ENST00000448903.6
ENST00000528815
ENST00000528815.5
EntrezGene:161
EntrezGene:AP2A2
g13544040_3p_s_at
GE53571
GO:0002376
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005764
GO:0005768
GO:0005773
GO:0005829
GO:0005886
GO:0005905
GO:0006810
GO:0006886
GO:0006897
GO:0007165
GO:0007267
GO:0008150
GO:0008289
GO:0009056
GO:0015031
GO:0016020
GO:0016192
GO:0019886
GO:0019899
GO:0019901
GO:0019904
GO:0030117
GO:0030122
GO:0030131
GO:0030666
GO:0030667
GO:0030669
GO:0030674
GO:0031410
GO:0032802
GO:0032991
GO:0034383
GO:0035615
GO:0036020
GO:0043226
GO:0043312
GO:0044403
GO:0045334
GO:0048013
GO:0048856
GO:0050690
GO:0060071
GO:0061024
GO:0072583
GO:0097718
GO:0101003
H0YDE9
H0YEG0
HGNC:562
HPA043040
Hs.19121.0.S2_3p_a_at
Hs.19121.0.S2_3p_at
Hs.19121.0.S2_3p_x_at
Hs.19121.1.S1_3p_a_at
Hs.19121.1.S1_3p_at
ILMN_1803779
IPR002553
IPR003164
IPR008152
IPR009028
IPR011989
IPR012295
IPR013041
IPR016024
IPR017104
MIM:607242
NM_001242837
NM_012305
NP_001229766
NP_036437
NR_144509
NR_144510
PF01602
PF02296
PF02883
PH_hs_0001684
SM00809
TC11000036.hg
UPI0000124FF5
UPI000047C6C1
UPI000050AA18
XM_011519929
XM_011519930
XP_011518231
XP_011518232
Participant Of
hasMember
Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane]
Ficolin-rich granule membrane proteins [plasma membrane]
Secretory granule membrane proteins [plasma membrane]
Other forms of this molecule
AP2A2(1-939) [endolysosome membrane]
AP2A2(1-939) [ficolin-1-rich granule membrane]
AP2A2(1-939) [secretory granule membrane]
AP2A2(1-939) [clathrin-coated endocytic vesicle membrane]
AP2A2(1-939) [cytosol]
Inferred To
AP2A2(1-939) [plasma membrane] (Bos taurus)
AP2A2(1-939) [plasma membrane] (Caenorhabditis elegans)
AP2A2(1-939) [plasma membrane] (Canis familiaris)
AP2A2(1-939) [plasma membrane] (Dictyostelium discoideum)
AP2A2(1-939) [plasma membrane] (Drosophila melanogaster)
AP2A2(1-939) [plasma membrane] (Gallus gallus)
AP2A2(1-939) [plasma membrane] (Mus musculus)
AP2A2(1-939) [plasma membrane] (Plasmodium falciparum)
AP2A2(1-939) [plasma membrane] (Rattus norvegicus)
AP2A2(1-939) [plasma membrane] (Saccharomyces cerevisiae)
AP2A2(1-939) [plasma membrane] (Schizosaccharomyces pombe)
AP2A2(1-939) [plasma membrane] (Sus scrofa)
AP2A2(1-939) [plasma membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_036437.1
,
NP_001229766.1
OpenTargets
ENSG00000183020
GeneCards
O94973
PRO
O94973
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
SHC1 [cytosol]
(R-HSA-74680)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
0.527
2
UniProt:Q96CW1 AP2M1
6
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.527
2
UniProt:P98078
3
DAB2 [lysosomal membrane]
(R-MMU-2980807)
DAB2 [cytosol]
(R-MMU-8862456)
DAB2 [plasma membrane]
(R-MMU-2980808)
0.499
2
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