Reactome | TERF2IP [nucleoplasm]

TERF2IP [nucleoplasm]

Stable Identifier

R-HSA-174873

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RAP1

Locations in the PathwayBrowser

Expand all

Cellular responses to external stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular Senescence (Homo sapiens)
    - DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
      - Telomere shortening during replicative exhaustion (Homo sapiens)
        
        Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        TERF2IP [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        TERF2IP [nucleoplasm] (Homo sapiens)

Reproduction (Homo sapiens)

- Meiosis (Homo sapiens)
  - Meiotic synapsis (Homo sapiens)
    - Telomeres cluster at the nuclear membrane (Homo sapiens)
      - Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        TERF2IP [nucleoplasm] (Homo sapiens)
      - Telomere Attachment Plate [nuclear envelope] (Homo sapiens)
        
        Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        TERF2IP [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NYB0 TERF2IP

Gene Names

TERF2IP, DRIP5, RAP1, PP8000

Chain

initiator methionine:1, chain:2-399

Reference Genes

BioGPS Gene:54386 TERF2IP

COSMIC (genes):TERF2IP TERF2IP

CTD Gene:54386 TERF2IP

dbSNP Gene:54386 TERF2IP

ENSEMBL:ENSG00000166848 TERF2IP

HGNC:19246 TERF2IP

KEGG Gene (Homo sapiens):54386 TERF2IP

Monarch:54386 TERF2IP

NCBI Gene:54386 TERF2IP

OMIM:605061 TERF2IP

UCSC:Q9NYB0 TERF2IP

Reference Transcript

RefSeq:NM_018975.3 TERF2IP

Other Identifiers

0003060576

11757968_s_at

16821083

18660

18749

1FEX

201174_s_at

3669094

3669095

3669096

3669097

3669098

3669104

3669107

3669108

3669109

3669110

38982_at

3936148

3K6G

4RQI

54386

6719

78205_at

7997281

A_23_P129704

AAF72711

AAH04465

AAH05841

AAH22428

AAH78171

AAL55783

AAQ14259

AC025287

AF250393

AF262988

AF289599

AK000669

AK298880

BAA91317

BAG60996

BC004465

BC005841

BC022428

BC078171

CAB018660

CAB018749

CCDS32491

CH471114

EAW95616

EAW95618

ENSG00000166848

ENSP00000300086

ENST00000300086

ENST00000300086.4

EntrezGene:54386

EntrezGene:TERF2IP

g9507032_3p_s_at

GE61445

GO:0000228

GO:0000723

GO:0000781

GO:0000783

GO:0000784

GO:0001933

GO:0003674

GO:0003677

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006259

GO:0006355

GO:0006464

GO:0006950

GO:0007004

GO:0007165

GO:0008150

GO:0009058

GO:0010569

GO:0010833

GO:0016233

GO:0016604

GO:0019899

GO:0019902

GO:0030870

GO:0031848

GO:0032204

GO:0032205

GO:0032991

GO:0033138

GO:0034641

GO:0042162

GO:0042592

GO:0043123

GO:0043226

GO:0048239

GO:0051092

GO:0051276

GO:0070187

GO:0070198

GO:0098505

GO:1901224

GO:1901985

H3BMI8

H3BR63

HGNC:19246

HPA006719

ILMN_1657983

IPR001357

IPR009057

IPR015010

IPR021661

IPR036420

IPR038104

IPR039595

MIM:605061

NM_018975

NP_061848

NR_144545

PF08914

PF11626

PF16589

PH_hs_0032420

TC16000621.hg

TERF2IP

TERF2IP-201

UPI0000136B77

Participant Of

hasComponent

Shelterin complex [nucleoplasm]

Inferred To

TERF2IP [nucleoplasm] (Bos taurus)

TERF2IP [nucleoplasm] (Canis familiaris)

TERF2IP [nucleoplasm] (Danio rerio)

TERF2IP [nucleoplasm] (Mus musculus)

TERF2IP [nucleoplasm] (Rattus norvegicus)

TERF2IP [nucleoplasm] (Sus scrofa)

TERF2IP [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_061848.2

OpenTargets

ENSG00000166848

GeneCards

Q9NYB0

PRO

Q9NYB0

Orphanet

23636

PDB

1FEX, 4RQI, 3K6G

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NUX5 POT1	1	POT1 [nucleoplasm] (R-HSA-174890)	0.643	4
UniProt:P25713 MT3	1	MT3 [cytosol] (R-HSA-5660396)	0.508	2
UniProt:O75347 TBCA	1	TBCA [cytosol] (R-HSA-379538)	0.508	2
UniProt:Q92620 DHX38	1	DHX38 [nucleoplasm] (R-HSA-72060)	0.508	2
UniProt:Q9NWV8 BABAM1	2	BABAM1 [nucleoplasm] (R-HSA-5682582) BABAM1 [cytosol] (R-HSA-5691418)	0.508	2
UniProt:P14550 AKR1A1	1	AKR1A1 [cytosol] (R-HSA-5661253)	0.508	2
UniProt:O95336 PGLS	1	PGLS [cytosol] (R-HSA-71294)	0.508	2
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) SUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200) SUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226)	0.508	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.508	2
UniProt:P61978 HNRNPK	2	SUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.508	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.508	2
UniProt:O95848 NUDT14	1	NUDT14 [cytosol] (R-HSA-6809220)	0.508	2
UniProt:Q15121 PEA15	1	PEA15 [cytosol] (R-HSA-5675204)	0.508	2
UniProt:P80297 MT1X	1	MT1X [cytosol] (R-HSA-5660400)	0.508	2
UniProt:P18510 IL1RN	1	IL1RN [plasma membrane] (R-HSA-445743)	0.508	2
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.508	2
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356)	0.508	2
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.508	2
UniProt:P37837 TALDO1	4	TALDO1 R192H [cytosol] (R-HSA-5659979) TALDO1 R192C [cytosol] (R-HSA-5659976) TALDO1 S171F [cytosol] (R-HSA-5659977) TALDO1 [cytosol] (R-HSA-71325)	0.508	2