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PSMB2 [nucleoplasm]
Stable Identifier
R-HSA-174335
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit beta type 2 , Proteasome component C7-I, Macropain subunit C7-I, Multicatalytic endopeptidase complex subunit C7-I
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB2 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB2 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB2 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB2 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB2 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB2 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Somitogenesis (Homo sapiens)
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB2 [nucleoplasm] (Homo sapiens)
TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB2 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB2 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB2 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49721 PSMB2
Gene Names
PSMB2
Chain
chain:1-201
Reference Genes
BioGPS Gene:5690 PSMB2
COSMIC (genes):PSMB2 PSMB2
CTD Gene:5690 PSMB2
dbSNP Gene:5690 PSMB2
ENSEMBL:ENSG00000126067 PSMB2
ENSEMBL_homo_sapiens_GENE:ENSG00000126067.12 PSMB2
HGNC:9539 PSMB2
KEGG Gene (Homo sapiens):5690 PSMB2
Monarch:5690 PSMB2
NCBI Gene:5690 PSMB2
OMIM:602175 PSMB2
UCSC:P49721 PSMB2
Reference Transcript
RefSeq:NM_002794.4 PSMB2
Other Identifiers
11728193_a_at
11760100_x_at
1310_at
16685144
18670642
18670643
18670644
18670645
18670646
18670648
18670649
200039_PM_s_at
200039_s_at
201404_PM_x_at
201404_x_at
238425_PM_at
238425_at
2406243
2406244
2406246
2406247
2406248
2406249
2406250
2406251
2406252
2406253
2406254
2406255
2406256
2406258
2406261
2406264
2406265
44267_at
52297_at
5690
63021_at
66197_at
7892894
7893061
7893333
7893853
7894501
7894926
7895180
7895602
7896651
7914834
A_24_P284893
A_32_P212333
D26599_at
GE57142
GO:0000502
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005839
GO:0010243
GO:0010498
GO:0014070
GO:0016020
GO:0019774
GO:0030163
GO:0043161
GO:0043226
GO:0051603
GO:0070062
HMNXSV003002055
Hs.285520.0.A1_3p_at
ILMN_1764794
PH_hs_0020020
TC01002498.hg
g4506194_3p_a_at
Participates
as a component of
26S proteasome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMB2 [cytosol]
Inferred To
PSMB2 [nucleoplasm]
(Bos taurus)
PSMB2 [nucleoplasm]
(Canis familiaris)
PSMB2 [nucleoplasm]
(Gallus gallus)
PSMB2 [nucleoplasm]
(Sus scrofa)
zgc:92282 [nucleoplasm]
(Danio rerio)
Proteasome subunit beta type-2 [nucleoplasm]
(Mus musculus)
pbs-4 [nucleoplasm]
(Caenorhabditis elegans)
Prosbeta4 [nucleoplasm]
(Drosophila melanogaster)
Psmb2 [nucleoplasm]
(Rattus norvegicus)
psmB2 [nucleoplasm]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_002785.1
ZINC - World Drugs
PSB2_HUMAN
Guide to Pharmacology - Targets
2405
OpenTargets
ENSG00000126067
ZINC - FDA approved
PSB2_HUMAN
ZINC - Substances
PSB2_HUMAN
ZINC target
P49721
PRO
P49721
PDB
7W3M
,
5T0C
,
7W3C
,
7QY7
,
5T0G
,
7QXX
,
7W3A
,
7W3K
,
5VFP
,
5T0I
,
7W3F
,
7W37
,
5VFO
,
7QYA
,
6RGQ
,
5T0J
,
4R3O
,
5GJR
,
7W38
,
5LEX
,
5A0Q
,
6MSK
,
7NAO
,
7V5M
,
8CVS
,
6WJD
,
6XMJ
,
5VFS
,
7NHT
,
5LEY
,
7NAN
,
8CVR
,
7QXP
,
5LEZ
,
6E5B
,
6KWY
,
7NAQ
,
5LF0
,
6WJN
,
7W39
,
5LN3
,
8CVT
,
7NAP
,
5LF4
,
5LF7
,
5LE5
,
6MSE
,
5M32
,
5T0H
,
7W3B
,
6MSG
,
7V5G
,
7QXN
,
6REY
,
7W3G
,
6MSH
,
7AWE
,
5VFQ
,
5GJQ
,
6MSJ
,
7LXV
,
8CXB
,
7W3H
,
7PG9
,
5VFR
,
7QYB
,
7QXW
,
4R67
,
7W3J
,
5VFT
,
7B12
,
6MSB
,
6R70
,
6AVO
,
5LF1
,
7W3I
,
7QXU
,
5LF6
,
5L4G
,
5VFU
,
5LF3
,
6MSD
ZINC - Investigational
PSB2_HUMAN
HPA
ENSG00000126067-PSMB2
GeneCards
P49721
Ensembl
ENST00000373237
,
ENSG00000126067
,
ENSP00000362334
Pharos - Targets
P49721
ZINC - Predictions - Purchasable
PSB2_HUMAN
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
7
UniProt:Q9Y2T1 AXIN2
4
AXIN2 [cytosol]
(R-HSA-3640821)
RibC-AXIN2 [cytosol]
(R-HSA-3640842)
Ub-RibC-AXIN2 [cytosol]
(R-HSA-3640859)
ub-AXIN2 [cytosol]
(R-HSA-4641131)
0.556
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.527
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
5
UniProt:P62333 PSMC6
2
PSMC6 [nucleoplasm]
(R-HSA-174319)
PSMC6 [cytosol]
(R-HSA-68783)
0.495
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
7
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