Reactome | Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex

Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex

Stable Identifier

R-HSA-174195

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex

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At the beginning of this reaction, 3 molecules of 'ubiquitin', and 1 molecule of 'cell cycle proteins:phospho-APC/C:Cdh1 complex' are present. At the end of this reaction, 1 molecule of 'multiubiquitinated cell cycle protein:APC/C:Cdh1 complex' is present.

This reaction takes place in the 'cytosol' and is mediated by the 'ubiquitin-protein ligase activity' of 'cell cycle proteins:phospho-APC/C:Cdh1 complex' (Rape et al.1996).

Literature References

PubMed ID	Title	Journal	Year
15678131	The anaphase-promoting complex: a key factor in the regulation of cell cycle Lorca, T, Bernis, C, Vigneron, S, Castro, A, Labbe, JC	Oncogene	2005
16413484	The processivity of multiubiquitination by the APC determines the order of substrate degradation Kirschner, MW, Rape, M, Reddy, SK	Cell	2006