C5b:C6:C7 translocates to the plasma membrane

Stable Identifier
R-HSA-173720
Type
Reaction [transition]
Species
Homo sapiens
Compartment
external side of plasma membrane
ReviewStatus
5/5
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C5b:C6:C7 translocates to the plasma membrane
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C7 recruitment of C7 results in a weak association of C5b:C6:C7 with the target cell membrane, through a poorly characterized molecular mechanism (Muller -Eberhard et al. 1986). C5b and C6 remains loosely bound to C3b until C5b binds to C7 and induces it to undergo a hydrophilic-amphiphilic transition. Hydrophobic binding regions for phospholipid are thereby exposed, and the trimolecular complex is endowed with a metastable membrane binding site. Membranebound C5b-7 inflicts no harm on a cell but marks it for further assault.
Literature References
PubMed ID Title Journal Year
3052276 Molecular organization and function of the complement system

Muller-Eberhard, HJ

Annu Rev Biochem 1988
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
Orthologous Events
C5b:C6:C7 translocates to the plasma membrane (Bos taurus)
C5b:C6:C7 translocates to the plasma membrane (Canis familiaris)
C5b:C6:C7 translocates to the plasma membrane (Gallus gallus)
C5b:C6:C7 translocates to the plasma membrane (Mus musculus)
C5b:C6:C7 translocates to the plasma membrane (Sus scrofa)
Authored
de Bono, B  (2004-08-04)
Reviewed
D'Eustachio, P  (2006-07-04)
Created
de Bono, B  (2006-02-16)
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