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p-2S-SMAD2/3:SMAD4 [nucleoplasm]
Stable Identifier
R-HSA-173511
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Phospho-R-SMAD:CO-SMAD complex
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Signaling by NODAL (Homo sapiens)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element (Homo sapiens)
SMAD2,3:SMAD4:FOXH1:Activin Response Element [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Homo sapiens)
SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of cell cycle genes (Homo sapiens)
CDKN1A gene transcription is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4:CDKN1A gene [nucleoplasm] (Homo sapiens)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
FOXG1 binds FOXO:SMAD complexes (Homo sapiens)
FOXG1:FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
FOXO1 and p-2S-SMAD2/3:SMAD4 bind MSTN gene promoter (Homo sapiens)
FOXO1:p-2S-SMAD2/3:SMAD4:MSTN gene [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Homo sapiens)
FOXO1,FOXO3,FOXO4:p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
FOXO:SMAD complex binds CDKN1A gene promoter (Homo sapiens)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4:CDKN1A gene [nucleoplasm] (Homo sapiens)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
MSTN gene expression is stimulated by FOXO1 and p-2S-SMAD2/3:SMAD4 (Homo sapiens)
FOXO1:p-2S-SMAD2/3:SMAD4:MSTN gene [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)
FOXO1,FOXO3 and SMAD3 bind TRIM63 gene promoter (Homo sapiens)
FOXO1,FOXO3:p-2S-SMAD2/3:SMAD4:TRIM63 gene [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
TRIM63 gene expression is stimulated by FOXO1 and FOXO3 (Homo sapiens)
FOXO1,FOXO3:p-2S-SMAD2/3:SMAD4:TRIM63 gene [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Homo sapiens)
p-2S-SMAD2/3:SMAD4:PARP1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:PARP1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
PPM1A dephosphorylates nuclear SMAD2/3 (Homo sapiens)
p-2S-SMAD2/3:SMAD4:PPM1A [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:PPM1A [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-SMAD2/3:SMAD4:TRIM33 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
TRIM33 monoubiquitinates SMAD4 (Homo sapiens)
p-SMAD2/3:SMAD4:TRIM33 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
Ubiquitination of SKI/SKIL by RNF111/SMURF2 (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:MEN1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex (Homo sapiens)
p-SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
SMAD2/3:SMAD4 complex positively regulates JUNB transcription (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SP1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SP1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it (Homo sapiens)
WWTR1:p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1:SMAD stimulates transcription of SMAD7 (Homo sapiens)
WWTR1:p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1:SMAD translocates to the nucleus (Homo sapiens)
WWTR1:p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGF-beta family members (Homo sapiens)
Signaling by Activin (Homo sapiens)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element (Homo sapiens)
SMAD2,3:SMAD4:FOXH1:Activin Response Element [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Homo sapiens)
p-2S-SMAD2/3:SMAD4:PARP1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:PARP1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
PPM1A dephosphorylates nuclear SMAD2/3 (Homo sapiens)
p-2S-SMAD2/3:SMAD4:PPM1A [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:PPM1A [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-SMAD2/3:SMAD4:TRIM33 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
TRIM33 monoubiquitinates SMAD4 (Homo sapiens)
p-SMAD2/3:SMAD4:TRIM33 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
Ubiquitination of SKI/SKIL by RNF111/SMURF2 (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:MEN1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex (Homo sapiens)
p-SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
SMAD2/3:SMAD4 complex positively regulates JUNB transcription (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SP1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SP1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it (Homo sapiens)
WWTR1:p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1:SMAD stimulates transcription of SMAD7 (Homo sapiens)
WWTR1:p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
WWTR1:SMAD translocates to the nucleus (Homo sapiens)
WWTR1:p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Homo sapiens)
Participants
components
2 x
p-2S-SMAD2/3 [nucleoplasm] (Homo sapiens)
SMAD4 [nucleoplasm] (Homo sapiens)
Participant Of
hasComponent
FOXO1,FOXO3,FOXO4:p-2S-SMAD2/3:SMAD4 [nucleoplasm]
FOXO1,FOXO3:p-2S-SMAD2/3:SMAD4:TRIM63 gene [nucleoplasm]
FOXO1,FOXO3:p-2S-SMAD2/3:SMAD4:Trim63 gene [nucleoplasm]
FOXO1:p-2S-SMAD2/3:SMAD4:MSTN gene [nucleoplasm]
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm]
p-2S-SMAD2/3:SMAD4:MEN1 [nucleoplasm]
p-2S-SMAD2/3:SMAD4:PARP1 [nucleoplasm]
p-2S-SMAD2/3:SMAD4:PPM1A [nucleoplasm]
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR [nucleoplasm]
p-2S-SMAD2/3:SMAD4:SP1 [nucleoplasm]
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm]
p-SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 [nucleoplasm]
p-SMAD2/3:SMAD4:TRIM33 [nucleoplasm]
SMAD2,3:SMAD4:FOXH1:Activin Response Element [nucleoplasm]
SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm]
WWTR1:p-2S-SMAD2/3:SMAD4 [nucleoplasm]
input
FOXO1 and p-2S-SMAD2/3:SMAD4 bind MSTN gene promoter
FOXO1,FOXO3 and SMAD3 bind TRIM63 gene promoter
FOXO1,FOXO3 and SMAD3 bind Trim63 gene promoter
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4
MEN1 binds SMAD2/3:SMAD4 heterotrimer
PARP1 binds SMAD2/3:SMAD4 heterotrimer
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9
PPM1A protein phosphatase binds phosphorylated SMAD2/3
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling
SMAD2/3:SMAD4 heterotrimer binds SP1
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer
TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling
output
The SMAD2/3:SMAD4 complex transfers to the nucleus
Ubiquitination of SKI/SKIL by Rnf111
Ubiquitination of SKI/SKIL by RNF111/SMURF2
This entity regulates
Positively
SMAD2/3:SMAD4 complex positively regulates JUNB transcription
Inferred To
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Danio rerio)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Drosophila melanogaster)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Mus musculus)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Sus scrofa)
p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Xenopus tropicalis)
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