Reactome | LDLRAP1 [plasma membrane]

LDLRAP1 [plasma membrane]

Stable Identifier

R-HSA-171143

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

low density lipoprotein receptor adapter protein 1, ARH, autosomal recessive hypercholesterolemia protein

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
        
        LDLRAP1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
        
        LDLRAP1 [plasma membrane] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
        
        LDLRAP1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
        
        LDLRAP1 [plasma membrane] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - LDLR is bound by DAB2 and ARH (Homo sapiens)
        
        DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
        
        LDLRAP1 [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
        
        LDLRAP1 [plasma membrane] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
        
        LDLRAP1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
        
        LDLRAP1 [plasma membrane] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
        
        LDLRAP1 [plasma membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
        
        LDLRAP1 [plasma membrane] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
        
        LDLRAP1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
        
        LDLRAP1 [plasma membrane] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
        
        LDLRAP1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
        
        LDLRAP1 [plasma membrane] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
        
        LDLRAP1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
        
        LDLRAP1 [plasma membrane] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
        
        LDLRAP1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Homo sapiens)
        
        DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)
        
        LDLRAP1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q5SW96 LDLRAP1

Gene Names

LDLRAP1, ARH

Chain

chain:1-308

Reference Genes

BioGPS Gene:26119 LDLRAP1

COSMIC (genes):LDLRAP1 LDLRAP1

CTD Gene:26119 LDLRAP1

dbSNP Gene:26119 LDLRAP1

ENSEMBL:ENSG00000157978 LDLRAP1

ENSEMBL_homo_sapiens_GENE:ENSG00000157978.12 LDLRAP1

HGNC:18640 LDLRAP1

KEGG Gene (Homo sapiens):26119 LDLRAP1

Monarch:26119 LDLRAP1

NCBI Gene:26119 LDLRAP1

OMIM:605747 LDLRAP1

UCSC:Q5SW96 LDLRAP1

Reference Transcript

RefSeq:NM_015627.2 LDLRAP1

Other Identifiers

11754815_a_at

16660933

221790_PM_s_at

221790_s_at

2326020

2326022

2326023

2326025

2326027

2326028

2326029

2326030

2326031

26119

57082_PM_at

57082_at

7899023

A_14_P127708

A_23_P158190

A_32_P216548

GE88697

GO:0001540

GO:0001784

GO:0005515

GO:0005546

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005856

GO:0005883

GO:0005886

GO:0006629

GO:0006897

GO:0006898

GO:0008202

GO:0008203

GO:0008289

GO:0009898

GO:0009925

GO:0016192

GO:0030159

GO:0030276

GO:0030301

GO:0030424

GO:0030669

GO:0031410

GO:0031623

GO:0034383

GO:0035591

GO:0035612

GO:0035615

GO:0035650

GO:0042632

GO:0042982

GO:0043226

GO:0043393

GO:0048260

GO:0050750

GO:0055037

GO:0060090

GO:0071345

GO:0072659

GO:0090118

GO:0090205

GO:1903076

GO:1904707

GO:1905581

GO:1905602

HMNXSV003019102

HMNXSV003026706

Hs.184482.0.S1_3p_s_at

ILMN_1809040

PH_hs_0010866

TC01000323.hg

Participates

as a member of

DAB2,LDLRAP1 [plasma membrane] (Homo sapiens)

as a component of

LRP2:LDLRAP1 [plasma membrane] (Homo sapiens)

This entity regulates

Positively

Other forms of this molecule

LDLRAP1 [clathrin-coated endocytic vesicle membrane]

Inferred To

Ldlrap1 [plasma membrane] (Mus musculus)

Ldlrap1 [plasma membrane] (Rattus norvegicus)

LDLRAP1 [plasma membrane] (Bos taurus)

LDLRAP1 [plasma membrane] (Canis familiaris)

LDLRAP1 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_056442.2

OpenTargets

ENSG00000157978

HPA

ENSG00000157978-LDLRAP1

GeneCards

Q5SW96

Ensembl

ENST00000374338, ENSP00000363458, ENSG00000157978

PRO

Q5SW96

Pharos - Targets

Q5SW96

Orphanet

16348

PDB

2G30

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H668 STN1	1	STN1 [nucleoplasm] (R-HSA-9668821)	0.85	12
UniProt:Q9UPT6 JIP3			0.718	6
UniProt:Q8NDX1-2 PSD4			0.718	6
UniProt:P63010-2 AP2B1			0.696	5
UniProt:P63010 AP2B1	4	AP2B1 [endolysosome membrane] (R-HSA-6784827) AP2B1 [plasma membrane] (R-HSA-167690) AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489) AP2B1 [cytosol] (R-HSA-182166)	0.681	4
UniProt:P38263 GID4			0.61	4
UniProt:P13378 HXD8			0.556	3
UniProt:Q6ZVH7 ESPNL	1	ESPNL [cytosol] (R-HSA-9671876)	0.556	3
UniProt:P31273 HOXC8	1	HOXC8 [nucleoplasm] (R-HSA-3222311)	0.556	8
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.556	3
UniProt:Q10567-3 AP1B1			0.556	3
UniProt:Q02548 PAX5	1	PAX5 [nucleoplasm] (R-HSA-158583)	0.556	3
UniProt:Q06616 YP174			0.556	3
UniProt:P43358 MAGA4			0.556	3
UniProt:A8MTQ0 NOTO	1	NOTO [nucleoplasm] (R-HSA-9796216)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.553	2
UniProt:Q6P5S2 LEG1H			0.488	2

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