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TGFB1 [extracellular region]
Stable Identifier
R-HSA-170838
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
TGF-beta-1, Transforming Growth Factor beta 1
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9BYQ6%20KRTAP4-11
Expand all
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of CEBPA (Homo sapiens)
TGFB1 [extracellular region] (Homo sapiens)
Expression of PPARG (Homo sapiens)
TGFB1 [extracellular region] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecans 2, (4) bind TGFB1 (Homo sapiens)
TGFB1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01137 TGFB1
Gene Names
TGFB1, TGFB
Chain
signal peptide:1-29, chain:30-278, chain:279-390
Reference Genes
BioGPS Gene:7040 TGFB1
COSMIC (genes):TGFB1 TGFB1
CTD Gene:7040 TGFB1
dbSNP Gene:7040 TGFB1
ENSEMBL:ENSG00000105329 TGFB1
ENSEMBL_homo_sapiens_GENE:ENSG00000105329.11 TGFB1
HGNC:11766 TGFB1
KEGG Gene (Homo sapiens):7040 TGFB1
Monarch:7040 TGFB1
NCBI Gene:7040 TGFB1
OMIM:190180 TGFB1
UCSC:P01137 TGFB1
Reference Transcript
RefSeq:NM_000660.6 TGFB1
Participates
as a member of
TGF beta [extracellular region] (Homo sapiens)
TGFB1,TGFB2 [extracellular region] (Homo sapiens)
as a component of
Syndecans 2, (4):TGFB1 [plasma membrane] (Homo sapiens)
Dimeric TGFB1 [extracellular region] (Homo sapiens)
as an input of
Syndecans 2, (4) bind TGFB1 (Homo sapiens)
This entity regulates
Negatively
Expression of PPARG
(Homo sapiens)
Expression of CEBPA
(Homo sapiens)
Other forms of this molecule
TGFB1(30-278) [extracellular region]
TGFB1(30-278) [Golgi lumen]
TGFB1 [Golgi lumen]
TGFB1(30-390) [Golgi lumen]
TGFB1 [plasma membrane]
TGFB1(30-278) [platelet alpha granule lumen]
Inferred To
B9D2 [extracellular region]
(Canis familiaris)
TGFB1 [extracellular region]
(Bos taurus)
TGFB1 [extracellular region]
(Gallus gallus)
TGFB1 [extracellular region]
(Sus scrofa)
mav [extracellular region]
(Drosophila melanogaster)
dbl-1 [extracellular region]
(Caenorhabditis elegans)
Tgfb1 [extracellular region]
(Mus musculus)
Tgfb1 [extracellular region]
(Rattus norvegicus)
daf-7 [extracellular region]
(Caenorhabditis elegans)
xx:ai39657 [extracellular region]
(Danio rerio)
Ghost homologue of TGFB1 [extracellular region]
(Xenopus tropicalis)
Homologues of TGFB1 [extracellular region]
(Caenorhabditis elegans)
Homologues of TGFB1 [extracellular region]
(Drosophila melanogaster)
dpp [extracellular region]
(Drosophila melanogaster)
unc-129 [extracellular region]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_000651.3
OpenTargets
ENSG00000105329
ZINC - Substances
TGFB1_HUMAN
GeneCards
P01137
ZINC target
P01137
PRO
P01137
Pharos - Targets
P01137
Orphanet
15606
ZINC - Predictions - Purchasable
TGFB1_HUMAN
HMDB Protein
HMDBP14566
PDB
1KLC
,
7Y1R
,
4KV5
,
7Y1T
,
5FFO
,
6P7J
,
6OM2
,
3KFD
,
1KLA
,
1KLD
,
5VQP
Interactors (33)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P37173 TGFBR2
9
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.886
11
UniProt:Q14766-1 LTBP1
0.637
4
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.604
3
UniProt:Q14392 LRC32
0.564
2
UniProt:P11464 PSG1
1
PSG1 [extracellular region]
(R-HSA-8870766)
0.558
3
UniProt:Q8IUG1 KRTAP1-3
1
KRTAP1-3 [cytosol]
(R-HSA-6809866)
0.556
3
UniProt:O60711 LPXN
0.556
3
UniProt:Q5TA81 LCE2C
1
LCE2C [cytosol]
(R-HSA-6814284)
0.556
3
UniProt:O14633 LCE2B
1
LCE2B [cytosol]
(R-HSA-6814295)
0.556
3
IntAct:EBI-22335676 CCSB ORF ID
0.556
3
UniProt:Q8NEC5 CATSPER1
1
CATSPER1 [plasma membrane]
(R-HSA-2534335)
0.556
3
UniProt:Q9BYE3 LCE3D
1
LCE3D [cytosol]
(R-HSA-6814297)
0.556
3
UniProt:Q5T751 LCE1C
1
LCE1C [cytosol]
(R-HSA-6814267)
0.556
3
UniProt:Q5T752 LCE1D
1
LCE1D [cytosol]
(R-HSA-6814283)
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:Q07627 KRTAP1-1
1
KRTAP1-1 [cytosol]
(R-HSA-6809855)
0.556
3
UniProt:Q5T7P2 LCE1A
1
LCE1A [cytosol]
(R-HSA-6814305)
0.556
3
UniProt:Q5TA76 LCE3A
1
LCE3A [cytosol]
(R-HSA-6814296)
0.556
3
UniProt:A0A0C3SFZ9 A0A0C3SFZ9
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q9BYQ6 KRTAP4-11
1
KRTAP4-11 [cytosol]
(R-HSA-6809960)
0.556
3
UniProt:P50222 MEOX2
0.556
3
UniProt:Q5TA77 LCE3B
1
LCE3B [cytosol]
(R-HSA-6814269)
0.556
3
IntAct:EBI-10171584 80125
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:P07237 P4HB
3
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
0.556
3
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
3
UniProt:Q12837 POU4F2
1
POU4F2 [nucleoplasm]
(R-HSA-6804414)
0.556
3
UniProt:P22105 TNXB
1
TNXB [extracellular region]
(R-HSA-2672026)
0.544
3
UniProt:Q12841 FSTL1
3
FSTL1 [extracellular region]
(R-HSA-201832)
p-FSTL1 [endoplasmic reticulum lumen]
(R-HSA-8957089)
FSTL1 [endoplasmic reticulum lumen]
(R-HSA-8956749)
0.544
2
UniProt:P07996 THBS1
5
THBS1 [endoplasmic reticulum lumen]
(R-HSA-5173263)
glc-fuc-THBS1 [endoplasmic reticulum lumen]
(R-HSA-5172997)
O-fuc-THBS1 [endoplasmic reticulum lumen]
(R-HSA-5173278)
THBS1 [platelet alpha granule lumen]
(R-HSA-114701)
THBS1 [extracellular region]
(R-HSA-66518)
0.525
2
UniProt:P01137 TGFB1
7
TGFB1 [extracellular region]
(R-HSA-170838)
TGFB1(30-278) [extracellular region]
(R-HSA-2395367)
TGFB1(30-278) [Golgi lumen]
(R-HSA-9736812)
TGFB1 [Golgi lumen]
(R-HSA-177108)
TGFB1(30-390) [Golgi lumen]
(R-HSA-114705)
TGFB1 [plasma membrane]
(R-HSA-5146781)
TGFB1(30-278) [platelet alpha granule lumen]
(R-HSA-65936)
0.522
2
UniProt:P06756 ITGAV
3
ITGAV(31-1048) [phagocytic vesicle]
(R-HSA-1236773)
ITGAV(31-1048) [specific granule membrane]
(R-HSA-6806145)
ITGAV(31-1048) [plasma membrane]
(R-HSA-210013)
0.488
2
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