Reactome | Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus

Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus

Stable Identifier

R-HSA-170044

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nuclear envelope

ReviewStatus

5/5

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Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus

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During interphase, cyclin B1:Cdc2 shuttles continuously in and out of the nucleus. Cyclin B1:Cdc2 is transported into the nucleus by an unusual mechanism that requires importin b but not importin a or Ran. Dissociation of the cyclin-B1:Cdc2:importin complex in the nucleus requires ATP and involves other yet unidentified nuclear factors (Takizawa et al.,1991).

Literature References

PubMed ID	Title	Journal	Year
9670027	MPF localization is controlled by nuclear export Pines, J, Hagting, A, Clute, P, Karlsson, C, Jackman, M	EMBO J	1998
10393926	Ran-independent nuclear import of cyclin B1-Cdc2 by importin beta Takizawa, CG, Morgan, DO, Weis, K	Proc Natl Acad Sci U S A	1999
9679058	Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1 Kornbluth, S, Powers, MA, Yang, J, Moore, JD, Brennan, J, Bardes, ES	Genes Dev	1998