Reactome | PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane

PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane

Stable Identifier

R-HSA-1676048

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane

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At the plasma membrane, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits form complexes with regulatory subunits. These complexes phosphorylate phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) to phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) (Stephens et al. 1997). The PI(4,5)P2 3-kinase complexes involved are: PI(4,5)P2 3-kinase catalytic subunit alpha isoform (PIK3CA) bound to PI 3-kinase regulatory subunit alpha/beta/gamma (PIK3R1/2/3); beta (PIK3CB) bound to PIK3R1/2/3; delta (PIK3CD) bound to PIK3R1/2/3; and gamma (PIK3CG) bound to PI 3-kinase regulatory subunit 5 (PIK3R5) or 6 (PIK3R6).

The following lists the above proteins with their corresponding literature references: PIK3CA:PIK3R1, PIK3CA:PIK3R2, PIK3CA:PIK3R3 (Dey et al. 1998, Vanhaesebroeck et al. 1997, Meier et al. 2004); PIK3CB:PIK3R1, PIK3CB:PIK3R2, PIK3CB:PIK3R3 (Meier et al. 2004); PIK3CD:PIK3R1, PIK3CD:PIK3R2, PIK3CD:PIK3R3 (Vanhaesebroeck et al. 1997, Meier et al. 2004); and PIK3CG:PIK3R5, PIK3CG:PIK3R6 (Voigt et al. 2006, Suire et al. 2005, Stoyanov et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
9094719	The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101 Hawkins, PT, Cadwallader, K, Smrcka, AS, Eguinoa, A, Lui, M, Coadwell, J, Cooke, F, Stephens, LR, Tempst, P, Thelen, M, Erdjument-Bromage, H	Cell	1997
9113989	P110delta, a novel phosphoinositide 3-kinase in leukocytes Downward, J, Higashi, K, Waterfield, MD, Volinia, S, Stein, R, Vanhaesebroeck, B, Warne, PH, Zvelebil, MJ, Kotani, K, Welham, MJ	Proc Natl Acad Sci U S A	1997
16476736	Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B Dorner, MB, Voigt, P, Schaefer, M	J Biol Chem	2006
15135396	Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms Lingaraj, T, Cook, JA, Meier, TI, Radding, JA, Smith, MC, Horn, C, Thomas, JE	Protein Expr Purif	2004
15797027	p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma Stephens, L, Coadwell, J, Suire, S, Davidson, K, Ferguson, GJ, Hawkins, P	Curr Biol	2005
9524259	Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor Furlanetto, RW, Dey, BR, Nissley, SP	Gene	1998
7624799	Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase Malek, D, Nurnberg, B, Dhand, R, Vanhaesebroeck, B, Volinia, S, Loubtchenkov, M, Stoyanov, B, Hanck, T, Stoyanova, S, Rubio, I	Science	1995