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Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase)
Stable Identifier
R-HSA-1655850
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
,
endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The FDFT1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
Literature References
PubMed ID
Title
Journal
Year
7685352
Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase
Shechter, I
,
Jiang, G
,
Conrad, DG
,
McKenzie, TL
J Biol Chem
1993
Participants
Input
FDFT1 gene [nucleoplasm]
(Homo sapiens)
Output
FDFT1 [endoplasmic reticulum membrane]
(Homo sapiens)
Participates
as an event of
PPARA activates gene expression (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
This event is regulated
Positively by
Regulator
PPARA:RXRA Coactivator complex [nucleoplasm]
(Homo sapiens)
Regulator
SREBP1A,1C,2:NF-Y:SP1:FDFT1 gene [nucleoplasm]
(Homo sapiens)
Authored
May, B (2011-09-28)
Reviewed
Liang, G (2012-08-26)
Kersten, S (2009-06-08)
Created
May, B (2011-10-13)
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