Inactivation of Myt1 kinase

Stable Identifier
R-HSA-162657
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At mitotic entry Plk1 phosphorylates and inhibits Myt1 activity. Cyclin B1-bound Cdc2, which is the target of Myt1, functions in a feedback loop and phosphorylates and further inhibits Myt1.

Literature References
PubMed ID Title Journal Year
12738781 Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate

Nakajima, H, Toyoshima-Morimoto, F, Taniguchi, E, Nishida, E

J Biol Chem 2003
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T210-PLK1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Created