AMPK phosphorylates PPARGC1A

Stable Identifier
R-HSA-1592244
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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As inferred from mouse, AMPK is activated by AMP and phosphorylates PGC-1alpha (PPARGC1A). It is hypothesized that this reaction connects energy depletion (low ATP, high AMP) to mitochondrial biogenesis (activation of PGC-1alpha).

Literature References
PubMed ID Title Journal Year
19112161 Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle

Gibala, MJ, McGee, SL, Garnham, AP, Howlett, KF, Snow, RJ, Hargreaves, M

J Appl Physiol 2009
21451146 An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1? and activates mitochondrial biogenesis in human skeletal muscle

Little, JP, Safdar, A, Bishop, D, Tarnopolsky, MA, Gibala, MJ

Am J Physiol Regul Integr Comp Physiol 2011
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Participant Of
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Catalyst Activity
Title
AMP-activated protein kinase activity of p-AMPK heterotrimer:AMP [nucleoplasm]
Physical Entity
Activity
Inferred From
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Created