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IgE [extracellular region]
Stable Identifier
R-HSA-1591211
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Ig G Antibody
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
Allergen dependent IgE bound FCERI aggregation (Homo sapiens)
FCERI:IgE [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
FCERI:IgE:Allergen aggregate [plasma membrane] (Homo sapiens)
FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
FCERI:IgE [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Phosphorylation of PLC-gamma (Homo sapiens)
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
Phosphorylation of TEC kinases by p-SYK (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Phosphorylation of SHC by SYK kinase (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
Phosphorylation of PKC-theta (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE binds FCERI (Homo sapiens)
FCERI:IgE [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE binds omalizumab (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
IgE:omalizumab [extracellular region] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
Phosphorylation of LAT by p-SYK (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
Phosphorylation of SYK (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
Phosphorylation of beta and gamma subunits by LYN (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
FCERI:IgE:Allergen aggregate [plasma membrane] (Homo sapiens)
FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
FCERI:IgE [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
Recruitment of SYK to p-FCERI gamma subunit (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
Role of LAT2/NTAL/LAB on calcium mobilization (Homo sapiens)
Phosphorylation of GAB2 by SYK/FYN (Homo sapiens)
SYK/FYN [plasma membrane] (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
Phosphorylation of NTAL by p-SYK/Lyn (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
IgE [extracellular region] (Homo sapiens)
General
In view of the highly variable nature of antibody proteins, this biological object is an approximate and fragmented representation of an IgM/IgD antibody, given the limitations of Ig chain enumeration in UniProt. A single mRNA transcript is alternatively spliced to give either IgM or IgD. Thus unactivated B cells contain both classes of antibody.
Participants
components
Ig Antibody Light Chain [extracellular region]
(Homo sapiens)
IgE Heavy Chain [extracellular region]
(Homo sapiens)
Participates
as a component of
IgE:omalizumab [extracellular region] (Homo sapiens)
FCERI:IgE [plasma membrane] (Homo sapiens)
p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
as an input of
IgE binds omalizumab (Homo sapiens)
IgE binds FCERI (Homo sapiens)
Inferred To
IgE [extracellular region]
(Bos taurus)
IgE [extracellular region]
(Canis familiaris)
IgE [extracellular region]
(Gallus gallus)
IgE [extracellular region]
(Mus musculus)
IgE [extracellular region]
(Rattus norvegicus)
IgE [extracellular region]
(Sus scrofa)
Cross References
ComplexPortal
CPX-6974
,
CPX-6973
,
CPX-6972
,
CPX-6971
,
CPX-6970
,
CPX-6969
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