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Translocation of ribosome by 3 bases in the 3' direction
Stable Identifier
R-HSA-156915
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Elongation (Homo sapiens)
Peptide chain elongation (Homo sapiens)
Translocation of ribosome by 3 bases in the 3' direction (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Following peptide bond formation, GTP-bound eEF2 catalyzes the translocation of the deacylated tRNA in the P-site and the peptidyl-tRNA in the A-site (the pre-translocation state) into the E- and P- sites (the post-translocation state), respectively. Thus, the mRNA advances by three bases to expose the next codon in the A-site. After translocation, GDP-bound eEF2 leaves the ribosome to allow another round of elongation. eEF2 is reactivated by the release of GDP and binds GTP for subsequent rounds.
This process is illustrated below with a peptidyl-tRNA with a growing peptide, a deacylated tRNA with an -OH and a ribosome with A,P and E sites to accommodate these three forms of tRNA is also shown.
Participants
Input
eEF1A:GTP:aminoacyl-tRNA complex [cytosol]
(Homo sapiens)
eEF2:GTP [cytosol]
(Homo sapiens)
Elongation complex with growing peptide chain [cytosol]
(Homo sapiens)
Output
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol]
(Homo sapiens)
eEF1A:GDP [cytosol]
(Homo sapiens)
eEF2:GDP [cytosol]
(Homo sapiens)
x 2
Pi [cytosol]
Participates
as an event of
Peptide chain elongation (Homo sapiens)
Inferred From
Translocation of ribosome by 3 bases in the 3' direction (Escherichia coli)
Authored
Gopinathrao, G (2005-02-09)
Created
Ortiz, PA (2005-03-17)
Kinzy, TG (2005-03-17)
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