Reactome | SRRM1 [nucleoplasm]

SRRM1 [nucleoplasm]

Stable Identifier

R-HSA-156781

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SRm160

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        SRRM1 [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        SRRM1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IYB3 SRRM1

Gene Names

SRRM1, SRM160

Chain

chain:1-904

Reference Genes

BioGPS Gene:10250 SRRM1

COSMIC (genes):SRRM1 SRRM1

CTD Gene:10250 SRRM1

dbSNP Gene:10250 SRRM1

ENSEMBL:ENSG00000133226 SRRM1

ENSEMBL_homo_sapiens_GENE:ENSG00000133226.19 SRRM1

HGNC:16638 SRRM1

KEGG Gene (Homo sapiens):10250 SRRM1

Monarch:10250 SRRM1

NCBI Gene:10250 SRRM1

OMIM:605975 SRRM1

UCSC:Q8IYB3 SRRM1

Reference Transcript

Other Identifiers

10250

11718775_a_at

11718776_s_at

11718777_at

11745984_a_at

11745985_s_at

11746679_a_at

11758235_s_at

16660828

201224_PM_s_at

201224_s_at

201225_PM_s_at

201225_s_at

2325531

2325536

2325537

2325544

2325545

2325550

2325551

2325553

2325554

2325556

2325557

2325558

2325562

2325565

2325566

2325567

2325572

2325573

2325574

2325575

2325576

2325578

2325579

2325581

2325582

2325584

2325585

2325586

3115345

3152682

3152684

3152685

4023615

4023616

4023626

4023627

41737_at

7898975

A_24_P11131

A_24_P264192

A_24_P679409

GE54421

GO:0000375

GO:0000398

GO:0003677

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005829

GO:0006397

GO:0008380

GO:0016071

GO:0016363

GO:0016607

GO:0043226

GO:0048024

GO:0051179

GO:0071013

HMNXSV003018893

HMNXSV003022025

HMNXSV003049441

Hs.18192.0.A1_3p_a_at

ILMN_1697670

PH_hs_0040525

g5032118_3p_a_at

Participates

as a component of

as an input of

Formation of the Spliceosomal Pre-B complex (Homo sapiens)

Other forms of this molecule

SRRM1 [cytosol]

Inferred To

Ghost homologue of SRRM1 [nucleoplasm] (Danio rerio)

Ghost homologue of SRRM1 [nucleoplasm] (Schizosaccharomyces pombe)

Ghost homologue of SRRM1 [nucleoplasm] (Xenopus tropicalis)

Srrm1 [nucleoplasm] (Drosophila melanogaster)

Srrm1 [nucleoplasm] (Mus musculus)

Srrm1 [nucleoplasm] (Rattus norvegicus)

SRRM1 [nucleoplasm] (Bos taurus)

SRRM1 [nucleoplasm] (Canis familiaris)

SRRM1 [nucleoplasm] (Dictyostelium discoideum)

SRRM1 [nucleoplasm] (Gallus gallus)

SRRM1 [nucleoplasm] (Plasmodium falciparum)

SRRM1 [nucleoplasm] (Sus scrofa)

JIP4 [nucleoplasm] (Saccharomyces cerevisiae)

rsr-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001290378.1, NP_001290377.1, NP_005830.2

OpenTargets

ENSG00000133226

GeneCards

Q8IYB3

HPA

ENSG00000133226-SRRM1

Ensembl

ENST00000323848, ENSP00000326261, ENSG00000133226

PRO

Q8IYB3

Pharos - Targets

Q8IYB3

PDB

1MP1, 7DVQ, 6FF7, 7ABH, 7ABI, 7ABG, 6FF4

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.758	4
UniProt:P49760 CLK2			0.718	6
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.613	3
UniProt:P49760-3 CLK2			0.556	3
UniProt:A7MD48 SRRM4			0.556	3
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2