Reactome | PLK1 [nucleoplasm]

PLK1 [nucleoplasm]

Stable Identifier

R-HSA-156720

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser for interactor UniProt:O95251 KAT7

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External Reference Information

External Reference

UniProt:P53350 PLK1

Gene Names

PLK1, PLK

Chain

initiator methionine:1, chain:2-603

Reference Genes

BioGPS Gene:5347 PLK1

COSMIC (genes):PLK1 PLK1

CTD Gene:5347 PLK1

dbSNP Gene:5347 PLK1

ENSEMBL:ENSG00000166851 PLK1

HGNC:9077 PLK1

KEGG Gene (Homo sapiens):5347 PLK1

Monarch:5347 PLK1

NCBI Gene:5347 PLK1

OMIM:602098 PLK1

UCSC:P53350 PLK1

Reference Transcript

RefSeq:NM_005030.5 PLK1

Other Identifiers

0104120750

11716726_a_at

11716727_x_at

11750302_a_at

16817017

1Q4K

1Q4O

1UMW

202240_at

2OGQ

2OJX

2OU7

2OWB

2RKU

2V5Q

2YAC

3137730

3653073

3653074

3653075

3653076

3653079

3653080

3653081

3653083

3653085

3653086

3653088

3653090

3653092

3653093

37228_at

3BZI

3C5L

3FC2

3FVH

3HIH

3HIK

3KB7

3P2W

3P2Z

3P34

3P35

3P36

3P37

3Q1I

3RQ7

3THB

4A4L

4A4O

4DFW

4E67

4E9C

4E9D

4H5X

4H71

4HAB

4HCO

4HY2

4J52

4J53

4LKL

4LKM

4O56

4O6W

4O9W

4RCP

4WHH

4WHK

4WHL

4X9R

4X9V

4X9W

51638

53229

5347

5J19

5NEI

5NFU

5NJE

5NMM

5NN1

5NN2

5TA6

5TA8

6AX4

7994109

A_14_P113539

A_24_P313504

A_33_P3298387

AAA36659

AAA56634

AAB36946

AAH02369

AAH03002

AAH14846

BC002369

BC003002

BC014846

CAA51837

CAA53536

CAA62260

CCDS10616

ENSG00000166851

ENSP00000300093

ENST00000300093

ENST00000300093.8

EntrezGene:5347

EntrezGene:PLK1

g4826915_3p_at

GO:0000003

GO:0000070

GO:0000086

GO:0000122

GO:0000132

GO:0000166

GO:0000228

GO:0000278

GO:0000281

GO:0000287

GO:0000775

GO:0000776

GO:0000777

GO:0000780

GO:0000785

GO:0000795

GO:0000922

GO:0000942

GO:0001578

GO:0003674

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005876

GO:0006464

GO:0006468

GO:0006511

GO:0006950

GO:0007010

GO:0007049

GO:0007059

GO:0007062

GO:0007077

GO:0007094

GO:0007098

GO:0007165

GO:0007346

GO:0008017

GO:0008092

GO:0008150

GO:0008219

GO:0009056

GO:0009058

GO:0010389

GO:0010800

GO:0010997

GO:0015630

GO:0016301

GO:0016310

GO:0016321

GO:0016567

GO:0016740

GO:0018105

GO:0019899

GO:0019901

GO:0022607

GO:0030071

GO:0030496

GO:0031145

GO:0031648

GO:0032436

GO:0032465

GO:0032991

GO:0033365

GO:0034451

GO:0034641

GO:0042802

GO:0043066

GO:0043167

GO:0043226

GO:0043393

GO:0045143

GO:0045184

GO:0045736

GO:0045862

GO:0051081

GO:0051233

GO:0051276

GO:0051301

GO:0051443

GO:0051726

GO:0061024

GO:0070194

GO:0071168

GO:0072425

GO:0090435

GO:0097711

GO:0140014

GO:1900182

GO:1901673

GO:1901990

GO:1902749

GO:1904668

GO:1904776

HGNC:9077

HPA051638

HPA053229

I3L2H5

I3L309

I3L387

ILMN_1736176

IPR000719

IPR000959

IPR008271

IPR011009

IPR017441

IPR033695

IPR033701

IPR033702

IPR036947

L19559

MIM:602098

NM_005030

NP_005021

PF00069

PF00659

PH_hs_0032688

PLK1

PLK1-201

SM00220

TC16000258.hg

U01038

U01038_at

U78073

UPI0000131BF9

X73458

X75932

X90725

Participant Of

output

Myosin phosphatase dephosphorylates PLK1

Other forms of this molecule

p-T210-PLK1 [nucleoplasm]

p-T210-PLK1 [cytosol]

PLK1 [cytosol]

Inferred To

PLK1 [nucleoplasm] (Bos taurus)

PLK1 [nucleoplasm] (Caenorhabditis elegans)

PLK1 [nucleoplasm] (Canis familiaris)

PLK1 [nucleoplasm] (Danio rerio)

PLK1 [nucleoplasm] (Dictyostelium discoideum)

PLK1 [nucleoplasm] (Drosophila melanogaster)

PLK1 [nucleoplasm] (Gallus gallus)

PLK1 [nucleoplasm] (Mus musculus)

PLK1 [nucleoplasm] (Plasmodium falciparum)

PLK1 [nucleoplasm] (Rattus norvegicus)

PLK1 [nucleoplasm] (Saccharomyces cerevisiae)

PLK1 [nucleoplasm] (Schizosaccharomyces pombe)

PLK1 [nucleoplasm] (Sus scrofa)

PLK1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_005021.2

ZINC - World Drugs

PLK1_HUMAN

OpenTargets

ENSG00000166851

ZINC - FDA approved

PLK1_HUMAN

ZINC - Substances

PLK1_HUMAN

ZINC target

P53350

ZINC - Biogenic

PLK1_HUMAN

PRO

P53350

PDB

4O9W, 2OJX, 2YAC, 2OWB, 4E67, 4O6W, 3P2W, 2OGQ, 3KB7, 4A4O, 5TA6, 4DFW, 4WHK, 1Q4O, 5NN1, 3THB, 4WHL, 3RQ7, 5NJE, 5NN2, 4X9R, 4X9V, 3C5L, 4J52, 5TA8, 6GY2, 2RKU, 4X9W, 1UMW, 4RCP, 5NFU, 4J53, 4HY2, 4LKL, 4E9C, 3FVH, 3HIK, 5NEI, 2OU7, 4LKM, 4E9D, 4H71, 6AX4, 5NMM, 3Q1I, 3FC2, 1Q4K, 2V5Q, 4A4L, 4HAB, 4O56, 4WHH, 3P34, 3BZI, 3P2Z, 3P35, 3P36, 4H5X, 3HIH, 4HCO, 5J19, 3P37

ZINC - Investigational

PLK1_HUMAN

ZINC - Metabolites

PLK1_HUMAN

GeneCards

P53350

ZINC - Predictions - Purchasable

PLK1_HUMAN

HMDB Protein

HMDBP01514

Interactors (53)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30307 CDC25C	8	CDC25C [nucleoplasm] (R-HSA-69741) p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) p-S216-CDC25C [cytosol] (R-HSA-75003) CDC25C [cytosol] (R-HSA-157879) p-S198-CDC25C [nucleoplasm] (R-HSA-156668) p-S198-CDC25C [cytosol] (R-HSA-8981697) p-S191-CDC25C [nucleoplasm] (R-HSA-6802968)	0.858	8
UniProt:P53350 PLK1	4	p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [cytosol] (R-HSA-164603)	0.797	4
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.737	6
UniProt:O96017 CHEK2	3	p-T68-CHEK2 [nucleoplasm] (R-HSA-113825) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784) CHEK2 [nucleoplasm] (R-HSA-113824)	0.72	7
UniProt:Q8IY92 SLX4	1	SLX4 [nucleoplasm] (R-HSA-5686477)	0.714	7
UniProt:Q9H0H5 RACGAP1	1	RACGAP1 [cytosol] (R-HSA-195122)	0.71	4
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.676	9
UniProt:O95251 KAT7	1	KAT7 [nucleoplasm] (R-HSA-3321823)	0.671	6
UniProt:Q6PGQ7 BORA	3	p-S252,S497,T501-BORA [cytosol] (R-HSA-3000330) BORA [cytosol] (R-HSA-2562607) p-S252-BORA [cytosol] (R-HSA-4086411)	0.669	4
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.657	3
UniProt:O60447 EVI5			0.656	3
UniProt:Q71F23-1 CENPU			0.65	5
UniProt:Q2NKX8 ERCC6L	1	ERCC6L [cytosol] (R-HSA-376250)	0.643	4
UniProt:O60271 SPAG9	1	SPAG9 [cytosol] (R-HSA-375975)	0.638	3
UniProt:O75665 OFD1	1	OFD1 [cytosol] (R-HSA-380318)	0.632	4
UniProt:Q99741 CDC6	4	CDC6 [cytosol] (R-HSA-113566) p-CDC6 [nucleoplasm] (R-HSA-5661317) p-CDC6 [cytosol] (R-HSA-68583) CDC6 [nucleoplasm] (R-HSA-68542)	0.632	6
UniProt:Q60838	5	DVL2 [cytosol] (R-MMU-201694) ub-DVL2 [cytosol] (R-MMU-4652689) phospho-p-DVL2 [clathrin-coated endocytic vesicle] (R-MMU-5138444) phospho-p-DVL2 [cytosol] (R-MMU-201706) phospho-pp-DVL2 [cytosol] (R-MMU-3772398)	0.632	12
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) SUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.632	5
UniProt:Q8TD19 NEK9	3	p-S29,T333,S750,S869-NEK9 [cytosol] (R-HSA-2984213) p-T333-NEK9 [cytosol] (R-HSA-2530600) p-S29,T210,T333,S750,S869-NEK9 [cytosol] (R-HSA-2984225)	0.625	5
UniProt:Q92889 ERCC4	1	ERCC4 [nucleoplasm] (R-HSA-67445)	0.623	4
UniProt:Q9NR09 BIRC6			0.602	4
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.602	7
UniProt:O75170 PP6R2			0.597	3
UniProt:P54132 BLM	2	4SUMO2,3-BLM [nucleoplasm] (R-HSA-4568883) BLM [nucleoplasm] (R-HSA-174881)	0.591	4
UniProt:P08107 HSP71			0.571	5
UniProt:Q9NYZ3 GTSE1	4	GTSE1 [cytosol] (R-HSA-8852264) p-T513,T526-GTSE1 [cytosol] (R-HSA-8852308) p-S435-GTSE1 [nucleoplasm] (R-HSA-8852332) p-S435-GTSE1 [cytosol] (R-HSA-8852316)	0.571	6
UniProt:Q92844 TANK	2	K63polyUb-TANK [cytosol] (R-HSA-5362480) TANK [cytosol] (R-HSA-933407)	0.57	3
UniProt:Q13188 STK3	4	p-T180-STK3(1-491) [cytosol] (R-HSA-2028274) p-T180-STK3(1-322) [cytosol] (R-HSA-2028696) STK3(323-491) [cytosol] (R-HSA-2028684) STK3(1-491) [cytosol] (R-HSA-2028280)	0.564	2
UniProt:Q16659 MAPK6	6	MAPK6 [nucleoplasm] (R-HSA-5692686) p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) p-S189 MAPK6 [cytosol] (R-HSA-5687019) MAPK6 [cytosol] (R-HSA-5686979) ub-MAPK6 [cytosol] (R-HSA-5687000)	0.547	2
UniProt:Q76N32 CEP68			0.544	2
UniProt:O14965 AURKA	6	AURKA [nucleoplasm] (R-HSA-4655443) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832)	0.525	4
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.524	4
UniProt:Q9Y4E8 USP15	1	USP15 [cytosol] (R-HSA-2173138)	0.508	2
UniProt:Q9Y6A4 CFA20			0.508	2
UniProt:Q9UKN8 GTF3C4	1	GTF3C4 [nucleoplasm] (R-HSA-83689)	0.508	2
UniProt:Q92769 HDAC2	2	SUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.508	2
UniProt:Q96R06 SPAG5			0.508	2
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.508	2
UniProt:P33991 MCM4	1	MCM4 [nucleoplasm] (R-HSA-68549)	0.508	2
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.508	2
UniProt:Q9Y5Q8 GTF3C5	1	GTF3C5 [nucleoplasm] (R-HSA-83693)	0.508	2
UniProt:Q14683 SMC1A	4	SMC1A [chromosome] (R-HSA-1638774) SMC1A [cytosol] (R-HSA-2484798) SMC1A [chromosome, centromeric region] (R-HSA-2466015) SMC1A [nucleoplasm] (R-HSA-64561)	0.508	2
UniProt:Q92949 FOXJ1			0.508	2
UniProt:Q14566 MCM6	1	MCM6 [nucleoplasm] (R-HSA-68553)	0.508	2
UniProt:Q15393 SF3B3	1	SF3B3 [nucleoplasm] (R-HSA-71973)	0.508	2
UniProt:Q00613 HSF1	11	p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) HSF1 [nucleoplasm] (R-HSA-5082385) hC36,103-HSF1 [cytosol] (R-HSA-4793916) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) HSF1 [cytosol] (R-HSA-3371452) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416)	0.508	2
UniProt:Q9Y6Y0 NS1BP			0.508	2
UniProt:Q8IXK0 PHC2	1	PHC2 [nucleoplasm] (R-HSA-389112)	0.508	2
UniProt:Q9UBC2 EPS15L1	2	EPS15L1 [plasma membrane] (R-HSA-182937) EPS15L1 [cytosol] (R-HSA-8935900)	0.508	2
UniProt:P70399-1 TP53BP1			0.499	2
UniProt:P54727 RAD23B	2	RAD23B [nucleoplasm] (R-HSA-62590) RAD23B [cytosol] (R-HSA-8850589)	0.489	2
UniProt:P23588 EIF4B	2	EIF4B [cytosol] (R-HSA-72589) p-S422-EIF4B [cytosol] (R-HSA-165773)	0.489	3
UniProt:Q99IB8-PRO_0000045602			0.463	4