Inactivation of Wee1 kinase

Stable Identifier
R-HSA-156699
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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*Plk1 is shown to phosphorylate Wee1A, an event that is likely critical for recognition and ubiquitination of Wee1A by SCF and therefore for the subsequent degradation of Wee1A . **Plk1 phosphorylates Wee1A at S53, creating the second phosphodegron, PD53. ** Evidence also exists in budding yeast that the budding yeast polo homolog Cdc5 directly phosphorylates and down-regulate the budding yeast Wee1 ortholog Swe1. Thus, polo kinase-dependent phosphorylation and degradation of Wee1A (or Swe1) is likely conserved throughout evolution and is critical for normal mitotic entry.

Literature References
PubMed ID Title Journal Year
15037762 Coupling morphogenesis to mitotic entry

Sakchaisri, K, Asano, S, Yu, LR, Shulewitz, MJ, Park, CJ, Park, JE, Cho, YW, Veenstra, TD, Thorner, J, Lee, KS

Proc Natl Acad Sci U S A 2004
15070733 M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

Watanabe, N, Arai, H, Nishihara, Y, Taniguchi, M, Watanabe, N, Hunter, T, Osada, H

Proc Natl Acad Sci U S A 2004
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T210-PLK1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Created