PTP-RO interacts with p-c-Kit complex

Stable Identifier
R-HSA-1433423
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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PTP-RO interacts with p-c-Kit complex
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Tyrosine phosphatase PTPRO associates constitutively with c-Kit independently of SCF stimulation. PTPRO undergoes phosphorylation upon SCF stimulation. The PTPRO binding site on c-Kit and the molecular mechanism by which c-Kit signaling is regulated by PTPRO have not been determined.
Literature References
PubMed ID Title Journal Year
10397721 The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor

London, R, Jiang, S, Avraham, H, Taniguchi, Y, Schinkmann, K

Blood 1999
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Output
Participates
as an event of
Orthologous Events
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PTP-RO interacts with p-c-Kit complex (Rattus norvegicus)
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Authored
Garapati, P V  (2011-07-11)
Reviewed
Rönnstrand, L  (2011-08-22)
Created
Garapati, P V  (2011-07-11)
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