Reactome | CASP7(207-303) [cytosol]

CASP7(207-303) [cytosol]

Stable Identifier

R-HSA-141642

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Caspase-7 (small subunit), Caspase-7 subunit p11

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External Reference Information

External Reference

UniProt:P55210 CASP7

Gene Names

CASP7, MCH3

Chain

initiator methionine:, propeptide:2-23, chain:24-198, propeptide:199-206, chain:207-303

Reference Genes

BioGPS Gene:840 CASP7

COSMIC (genes):CASP7 CASP7

CTD Gene:840 CASP7

dbSNP Gene:840 CASP7

ENSEMBL:ENSG00000165806 CASP7

ENSEMBL_homo_sapiens_GENE:ENSG00000165806.21 CASP7

HGNC:1508 CASP7

KEGG Gene (Homo sapiens):840 CASP7

Monarch:840 CASP7

NCBI Gene:840 CASP7

OMIM:601761 CASP7

UCSC:P55210 CASP7

Reference Transcript

Other Identifiers

11719647_a_at

11719648_a_at

11728226_a_at

11750198_a_at

16709386

207181_PM_s_at

207181_s_at

3264950

3264951

3264952

3264953

3264954

3264956

3264957

3264959

3264978

3264979

3264980

3264981

3264982

3264984

3264986

3264987

3264988

3264989

3264991

38281_at

7930577

840

A_14_P117796

A_23_P12572

GE59348

GO:0003723

GO:0003824

GO:0004190

GO:0004197

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006508

GO:0006915

GO:0007507

GO:0008152

GO:0008233

GO:0008234

GO:0009411

GO:0012501

GO:0016485

GO:0016787

GO:0030154

GO:0030163

GO:0032991

GO:0042060

GO:0042742

GO:0043226

GO:0044346

GO:0048856

GO:0051146

GO:0051402

GO:0051604

GO:0061024

GO:0070227

GO:0071222

GO:0071887

GO:0072734

GO:0097153

GO:0097194

GO:0097200

GO:0098542

GO:0140096

GO:1905686

HMNXSV003037170

ILMN_1730332

ILMN_2362974

ILMN_2373763

PH_hs_0000966

TC10000825.hg

U67319_at

g4502580_3p_a_at

Participates

as a component of

CASP7(24-198):CASP7(207-303) [cytosol] (Homo sapiens)

Other forms of this molecule

CASP7(24-198) [nucleoplasm]

CASP7(207-303) [nucleoplasm]

CASP7(2-303) [cytosol]

CASP7(24-198) [cytosol]

Inferred To

casp7 [cytosol] (Xenopus tropicalis)

zgc:110595 [cytosol] (Danio rerio)

Casp7 [cytosol] (Mus musculus)

Casp7 [cytosol] (Rattus norvegicus)

CASP7 [cytosol] (Bos taurus)

CASP7 [cytosol] (Canis familiaris)

CASP7 [cytosol] (Gallus gallus)

CASP7 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001307840.1, NP_001253987.1, NP_203126.1, NP_203125.1, NP_001218.1, NP_001253985.1, NP_203124.1, NP_001253986.1

Guide to Pharmacology - Targets

1623

OpenTargets

ENSG00000165806

ZINC - Substances

CASP7_HUMAN

ZINC target

P55210

PRO

P55210

PDB

3IBC, 1K86, 4LSZ, 2QLB, 4JB8, 5V6U, 3H1P, 1K88, 3EDR, 1GQF, 1I4O, 3R5K, 3IBF, 1I51, 5V6Z, 4FEA, 2QLF, 5K20, 4ZVO, 8DJ3, 1SHL, 2QLJ, 1SHJ, 7WZS, 5IC6, 1KMC, 1F1J, 4HQR, 2QL7, 4JR2, 4ZVT, 4JR1, 4ZVS, 4JJ8, 4HQ0, 4ZVU, 4FDL, 2QL9, 2QL5, 4ZVP, 8DGZ, 4ZVR, 4ZVQ

ZINC - Investigational

CASP7_HUMAN

HPA

ENSG00000165806-CASP7

GeneCards

P55210

Ensembl

ENST00000369315, ENST00000345633, ENSP00000298701, ENSG00000165806, ENSP00000478285, ENST00000614447, ENSP00000480584, ENST00000369331, ENST00000621607, ENSP00000358337, ENST00000369318, ENST00000452490, ENST00000621345, ENSP00000358324, ENSP00000398107, ENSP00000358321, ENSP00000478999

Pharos - Targets

P55210

ZINC - Predictions - Purchasable

CASP7_HUMAN

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P98170 XIAP	3	XIAP [nucleoplasm] (R-HSA-3322366) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [cytosol] (R-HSA-50849)	0.786	4
UniProt:P21673 SAT1	1	SAT1 [cytosol] (R-HSA-351236)	0.718	6
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653)	0.619	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	12
UniProt:P17405 SMPD1	1	SMPD1 [lysosomal lumen] (R-HSA-1605710)	0.537	6
UniProt:Q13490 BIRC2	5	K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.524	2
UniProt:Q16236 NFE2L2	13	p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-NFE2L2 [cytosol] (R-HSA-9758077) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.508	2