Inactivation of APC/C via CDC20 sequestration

Stable Identifier
R-HSA-141429
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In the sequestration model, the Mad2 molecules that dissociate from unattached kinetochores are perceived to bind to Cdc20, a protein that recruits specific substrates to the APC/C. Consequently, Mad2 indirectly inhibits the APC/C by sequestering its activator, Cdc20. This requires interaction between Mad1 and Mad2. Cdc20 and Mad1 bind to the same site on Mad2.

Literature References
Participants
Participant Of
Orthologous Events
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Reviewed
Created