Reactome | MAD2*CDC20 complex [cytosol]

MAD2*CDC20 complex [cytosol]

Stable Identifier

R-HSA-141408

Type

Complex

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
      - Inactivation of APC/C via CDC20 sequestration (Homo sapiens)
        
        MAD2*CDC20 complex [cytosol] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
        
        Inactivation of APC/C via CDC20 sequestration (Homo sapiens)
        
        MAD2*CDC20 complex [cytosol] (Homo sapiens)

General

Activated Mad2 upon release from kinetochores binds and sequesters Cdc20 from activating the APC.

Participants

components

Participant Of

output

Inactivation of APC/C via CDC20 sequestration

Inferred To

MAD2*CDC20 complex [cytosol] (Bos taurus)

MAD2*CDC20 complex [cytosol] (Caenorhabditis elegans)

MAD2*CDC20 complex [cytosol] (Canis familiaris)

MAD2*CDC20 complex [cytosol] (Danio rerio)

MAD2*CDC20 complex [cytosol] (Dictyostelium discoideum)

MAD2*CDC20 complex [cytosol] (Drosophila melanogaster)

MAD2*CDC20 complex [cytosol] (Gallus gallus)

MAD2*CDC20 complex [cytosol] (Mus musculus)

MAD2*CDC20 complex [cytosol] (Rattus norvegicus)

MAD2*CDC20 complex [cytosol] (Saccharomyces cerevisiae)

MAD2*CDC20 complex [cytosol] (Schizosaccharomyces pombe)

MAD2*CDC20 complex [cytosol] (Sus scrofa)

MAD2*CDC20 complex [cytosol] (Xenopus tropicalis)

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