Reactome | TP53 stimulates BBC3 (PUMA) expression

TP53 stimulates BBC3 (PUMA) expression

Stable Identifier

R-HSA-139913

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)

General

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TP53 (p53) stimulates the transcription of BBC3 (PUMA) (p53 upregulated modulator of apoptosis) (Nakano and Vousden 2001). The transcription of BBC3 is also stimulated by p53 family members TP63 (p63) and TP73 (p73) (Bergamaschi et al. 2004, Patel et al. 2008). ASPP proteins PPP1R13B (ASPP1) and TP53BP2 (ASPP2) form a complex with p53 family members and enhance transcriptional activation of BBC3 (Bergamaschi et al. 2004, Patel et al. 2008, Wilson et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23365256	ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo Feinstein, E, Wilson, AM, Morquette, B, Abdouh, M, Bernier, G, Unsain, N, Di Polo, A, Barker, PA	J. Neurosci.	2013
18676979	Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax Autore, F, Fraternali, F, Ladbury, JE, Patel, S, George, R, Nikolova, PV	Nucleic Acids Res.	2008
14729977	ASPP1 and ASPP2: common activators of p53 family members Samuels, Y, Lu, X, Jin, B, Duraisingham, S, Bergamaschi, D, Crook, T	Mol. Cell. Biol.	2004
11572983	Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals Lutz, RJ, Zhu, L, Gu, Z, Flemington, C, Han, J, Chittenden, T, Zambetti, GP, Houghton, AB	Proc. Natl. Acad. Sci. U.S.A.	2001
11463392	PUMA, a novel proapoptotic gene, is induced by p53 Nakano, K, Vousden, KH	Mol Cell	2001

Participants

Input

BBC3 gene [nucleoplasm] (Homo sapiens)

Output

BBC3 [cytosol] (Homo sapiens)

Participates

as an event of

This event is regulated

Positively by

Regulator

(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)

Active Unit

(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm]

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Hardwick, JM (2004-08-09)

Tsujimoto, Y (2004-08-09)