Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex

Stable Identifier
R-HSA-1363328
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Phosphorylated p130 (RBL2) binds SCF (Skp2) ubiquitin ligase in complex with Cks1. Phosphorylation of p130 (RBL2) serine residue S672 by CDK4/6 is critical for this interaction.

Literature References
PubMed ID Title Journal Year
12435635 The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2)

Tedesco, D, Lukas, J, Reed, SI

Genes Dev 2002
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created