Dephosphorylation of p130 (RBL2) by PP2A

Stable Identifier
R-HSA-1363276
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Dephosphorylation of p107 by PP2A
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Dephosphorylation of p130 (RBL2) by PP2A complex containing either PPP2R3B (B" beta) or PPP2R2A (B alpha) regulatory subunit plays a role in maintaining the equilibrium of hyperphosphorylated and hypophosphorylated p130 (RBL2), through counteracting action of cyclin dependent kinases (CDKs). It is assumed that PP2A dephosphorylates p130 (RBL2) on all three phosphorylation sites, but further experiments are needed to confirm this.

Literature References
PubMed ID Title Journal Year
20663872 B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation

Jayadeva, G, Kurimchak, A, Garriga, J, Sotillo, E, Davis, AJ, Haines, DS, Mumby, M, Grana, X

J Biol Chem 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphoprotein phosphatase activity of PP2A [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created