Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1

Stable Identifier
R-HSA-1362300
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
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In G0 and early G1, expression of E2F target genes such as Cyclin A, E2F1, CDC2 and MYBL2 is inhibited by complexes containing p130 (RBL2) and p107 (RBL1), respectively, and histone deacetylase HDAC1.
Literature References
PubMed ID Title Journal Year
11959842 E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex

Catchpole, S, Dynlacht, BD, te Riele, H, Dannenberg, JH, Watson, RJ, Rayman, JB, Indjeian, VB, Takahashi, Y

Genes Dev 2002
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Cross References
BioModels Database
Authored
Orlic-Milacic, M  (2011-06-14)
Reviewed
MacPherson, D  (2011-08-25)
Created
Orlic-Milacic, M  (2011-06-09)
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