TWIK-releated acid-sensitive K+ channel (TASK)

Stable Identifier
R-HSA-1299316
Type
Pathway
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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TWIK-releated acid-sensitive K+ channel (TASK)
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TASK 1 and 3 are closely related both structurally and functionally. TASK1 and TASK3 are activated by extracellular acidification and inhibited by decrease in pH. TASK 1 and Task 3 form functional homodimers and heterodimers, however the biophysical properties of TAS1 and TASK3 heteromers are different form parent subunit properties.
Literature References
PubMed ID Title Journal Year
18824070 Altered neuronal expression of TASK1 and TASK3 potassium channels in rodent and human autoimmune CNS inflammation

Melzer, N, Meuth, SG, Bittner, S, Kanyshkov, T, Wiendl, H, Budde, T, Kieseier, BC

Neurosci Lett 2008
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
potassium ion transmembrane transport (0071805)
Orthologous Events
TWIK-releated acid-sensitive K+ channel (TASK) (Bos taurus)
TWIK-releated acid-sensitive K+ channel (TASK) (Caenorhabditis elegans)
TWIK-releated acid-sensitive K+ channel (TASK) (Canis familiaris)
TWIK-releated acid-sensitive K+ channel (TASK) (Drosophila melanogaster)
TWIK-releated acid-sensitive K+ channel (TASK) (Gallus gallus)
TWIK-releated acid-sensitive K+ channel (TASK) (Mus musculus)
TWIK-releated acid-sensitive K+ channel (TASK) (Rattus norvegicus)
TWIK-releated acid-sensitive K+ channel (TASK) (Saccharomyces cerevisiae)
TWIK-releated acid-sensitive K+ channel (TASK) (Sus scrofa)
TWIK-releated acid-sensitive K+ channel (TASK) (Xenopus tropicalis)
Authored
Mahajan, SS  (2011-05-22)
Reviewed
Jassal, B  (2010-09-23)
Created
Mahajan, SS  (2011-05-23)
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