Reactome | GFAP [cytosol]

GFAP [cytosol]

Stable Identifier

R-HSA-1253311

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser for interactor UniProt:P07196 NEFL

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External Reference Information

External Reference

UniProt:P14136 GFAP

Gene Names

GFAP

Chain

chain:1-432

Reference Genes

BioGPS Gene:2670 GFAP

COSMIC (genes):GFAP GFAP

CTD Gene:2670 GFAP

dbSNP Gene:2670 GFAP

ENSEMBL:ENSG00000131095 GFAP

HGNC:4235 GFAP

KEGG Gene (Homo sapiens):2670 GFAP

Monarch:2670 GFAP

NCBI Gene:2670 GFAP

OMIM:137780 GFAP

UCSC:P14136 GFAP

Reference Transcript

Other Identifiers

0006420377

11726992_a_at

11726993_a_at

11726994_s_at

11731327_at

11749591_s_at

11749592_x_at

11754748_x_at

11755455_x_at

16845774

16845777

203540_at

222197_s_at

229259_at

2599633

2670

3759408

3759409

3759411

3759412

3759413

3759414

3759415

3759416

3759417

3759418

3759420

3759423

3759424

3759425

3759426

3759427

3759428

3759430

3759433

3759434

3759435

3759437

3759439

3759440

3759441

3759442

3759443

3759444

40185_at

49593_at

49596_g_at

56030

62313_at

63513

6A9P

75040_at

8016128

82303_at

A0A1W2PQ25

A0A1W2PR46

A0A1W2PRT3

A0A1X7SBR3

A0A1X7SCE1

A_23_P66593

A_24_P31165

A_24_P59786

A_24_P623768

A_33_P3335895

AAA52528

AAA52529

AAB22581

AAH13596

AAH41765

AAH62609

AAL16662

AAN87903

AAN87904

AAN87907

AC015936

AF419299

AJ306447

AK128790

AK222683

AK315398

AL133013

AY142187

AY142188

AY142191

B4DIR1

BAC87610

BAD96403

BAG37791

BC013596

BC041765

BC062609

CAB000039

CAB61354

CAC69881

CCDS11491

CCDS45708

CCDS59296

CH471178

EAW51570

EAW51571

ENSG00000131095

ENSP00000403962

ENSP00000466598

ENSP00000491088

ENST00000435360

ENST00000435360.7

ENST00000588735

ENST00000588735.2

ENST00000638281

ENST00000638281.1

EntrezGene:2670

EntrezGene:GFAP

g4503978_3p_at

GE594616

GE61325

GE845063

GFAP

GFAP-203

GFAP-214

GFAP-225

GO:0003674

GO:0005198

GO:0005200

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0005856

GO:0005882

GO:0006914

GO:0007010

GO:0008150

GO:0009056

GO:0022607

GO:0042802

GO:0043226

GO:0043254

GO:0045109

GO:0045111

GO:0065003

GO:1904714

HGNC:4235

HPA056030

HPA063513

Hs.21258.1.S1_3p_at

Hs.286055.3.S1_3p_at

ILMN_1697176

IPR006821

IPR018039

IPR027701

IPR039008

IPR042180

J04569

K7EJK1

K7EJU1

K7EKD1

K7EKH9

K7ELP4

K7EMP8

K7EPI4

M26638

MIM:137780

MIM:203450

NM_001131019

NM_001242376

NM_002055

NP_001124491

NP_001229305

NP_002046

PF00038

PF04732

PH_hs_0019272

S40719

S40719_s_at

SM01391

TC17001587.hg

TC17001588.hg

TC17002662.hg

TC17002663.hg

UPI0000000DCF

UPI0000680AD5

UPI0000D62349

XM_024450691

XM_024450692

XM_024450693

XP_024306459

XP_024306460

XP_024306461

Participant Of

output

GFAP gene expression is inhibited by ERBB4:TAB2:NCOR1

Other forms of this molecule

p-GFAP [lysosomal membrane]

GFAP [lysosomal membrane]

Cross References

RefSeq

NP_002046.1, NP_001229305.1, NP_001124491.1

OpenTargets

ENSG00000131095

GeneCards

P14136

PRO

P14136

Orphanet

16117

PDB

6A9P

Interactors (66)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.795	8
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.795	8
UniProt:P14136 GFAP	3	GFAP [lysosomal membrane] (R-HSA-9625195) p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [cytosol] (R-HSA-1253311)	0.764	6
UniProt:Q9UBU9 NXF1	2	NXF1 [nucleoplasm] (R-HSA-111690) NXF1 [cytosol] (R-HSA-156481)	0.764	6
UniProt:Q8TCE9 PPL13			0.764	6
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.718	6
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.696	5
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.696	5
UniProt:P08727 KRT19	1	KRT19 [cytosol] (R-HSA-6809617)	0.696	5
UniProt:P13646 KRT13	1	KRT13 [cytosol] (R-HSA-6809591)	0.696	5
UniProt:Q8WWB5 PIHD2			0.666	4
UniProt:Q96HL8 SH3Y1			0.666	4
UniProt:P08670 VIM	11	VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323)	0.621	3
UniProt:A1A4E9 A1A4E9			0.61	4
UniProt:I6L9F6 I6L9F6			0.601	4
UniProt:P53829 CAF40			0.556	3
UniProt:P28272 PYRD			0.556	3
UniProt:Q9Y247 FA50B			0.556	3
UniProt:Q8IYR0 CF206			0.556	3
UniProt:P25791 LMO2	1	LMO2 [nucleoplasm] (R-HSA-8956513)	0.556	3
UniProt:P47041	1	PRR5 [cytosol] (R-SCE-6795323-2)	0.556	3
UniProt:P00540 MOS			0.556	3
UniProt:Q53FD0 ZC21C			0.556	3
UniProt:P25343 RV161			0.556	3
UniProt:P47121 YJ41			0.556	3
UniProt:Q13490 BIRC2	5	K48pUb-BIRC2 [cytosol] (R-HSA-5675479) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2 [cytosol] (R-HSA-50847) BIRC2(373-618) [cytosol] (R-HSA-202931)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:P35398 RORA	3	RORA [nucleoplasm] (R-HSA-400325) SUMO2-K240-RORA [nucleoplasm] (R-HSA-4719425) SUMO1-K240-RORA [nucleoplasm] (R-HSA-4719422)	0.556	3
UniProt:O75928 PIAS2	1	PIAS2 [nucleoplasm] (R-HSA-2993787)	0.556	3
IntAct:EBI-11522220 LSB3			0.556	3
UniProt:P38265 CENPL			0.556	3
UniProt:Q6ZU52 K0408			0.553	2
UniProt:O00151 PDLI1			0.553	3
UniProt:Q9H4K1 RIBC2			0.553	2
UniProt:Q2TBE0 C19L2			0.488	2
UniProt:Q05086-3 UBE3A			0.488	2
UniProt:P57075-2 UBASH3A			0.488	2
UniProt:Q96D03 DDT4L			0.488	2
UniProt:P17661 DES	1	DES [cytosol] (R-HSA-390570)	0.488	4
UniProt:Q05BL1 Q05BL1			0.488	2
UniProt:Q9HC98-4 NEK6			0.488	2
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.488	2
UniProt:Q96T49 PP16B			0.488	2
UniProt:Q8NI38 IKBD			0.488	2
UniProt:Q7L775 EPMIP			0.488	2
UniProt:Q9H0I2 ENKD1			0.488	2
UniProt:A2RUH7 MBPHL			0.488	2
UniProt:Q8WUE5 CT55			0.488	2
UniProt:Q96BZ8 LENG1			0.488	2
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.488	2
UniProt:Q96HA8 NTAQ1			0.488	2
IntAct:EBI-11957986 HOMEZ			0.488	2
UniProt:Q6NYC8 PPR18			0.488	2
UniProt:Q2TAC2-2 CCDC57			0.488	2
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.488	2
UniProt:Q9BWT7 CAR10			0.488	2
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.488	2
UniProt:Q8IYX1 TBC21			0.488	4
UniProt:P45984 MAPK9	3	p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319) MAPK9 [cytosol] (R-HSA-450355) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293)	0.488	2
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.488	2
UniProt:Q9NU19 TB22B			0.488	2
UniProt:G2XKQ0 SUMO5			0.488	2
UniProt:Q6A163 KRT39	1	KRT39 [cytosol] (R-HSA-6809592)	0.488	2
UniProt:Q8N720 ZNF655	1	ZNF655 [nucleoplasm] (R-HSA-2127575)	0.488	2
UniProt:Q9NYB9-2 ABI2			0.488	2
UniProt:Q6NX45 ZNF774	1	ZNF774 [nucleoplasm] (R-HSA-3110232)	0.488	4