Reactome | GRPEL1 [mitochondrial inner membrane]

GRPEL1 [mitochondrial inner membrane]

Stable Identifier

R-HSA-1252062

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

GrpE protein homolog 1, mitochondrial, GRPE1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9HAV7 GRPEL1

Gene Names

GRPEL1, GREPEL1

Chain

transit peptide:1-27, chain:28-217

Reference Genes

BioGPS Gene:80273 GRPEL1

COSMIC (genes):GRPEL1 GRPEL1

CTD Gene:80273 GRPEL1

dbSNP Gene:80273 GRPEL1

ENSEMBL:ENSG00000109519 GRPEL1

ENSEMBL_homo_sapiens_GENE:ENSG00000109519.14 GRPEL1

HGNC:19696 GRPEL1

KEGG Gene (Homo sapiens):80273 GRPEL1

Monarch:80273 GRPEL1

NCBI Gene:80273 GRPEL1

OMIM:606173 GRPEL1

UCSC:Q9HAV7 GRPEL1

Reference Transcript

RefSeq:NM_025196.3 GRPEL1

Other Identifiers

11739112_a_at

11749311_a_at

16974096

212432_PM_at

212432_at

212434_PM_at

212434_at

2759406

2759407

2759408

2759409

2759411

2759412

2759413

2759418

2759419

39786_at

67163_at

80273

8099246

A_24_P166045

A_33_P3522525

GE54623

GE580260

GO:0000774

GO:0001405

GO:0005515

GO:0005634

GO:0005654

GO:0005739

GO:0005743

GO:0005744

GO:0005759

GO:0006457

GO:0006886

GO:0007005

GO:0030150

GO:0042802

GO:0042803

GO:0043226

GO:0051082

GO:0051087

GO:0055085

GO:0098772

HMNXSV003005722

Hs.151903.0.S1_3p_at

Hs.151903.0.S2_3p_at

ILMN_1670817

PH_hs_0029233

TC04001007.hg

Participates

as a member of

GRPEL1,2 [mitochondrial inner membrane] (Homo sapiens)

Cross References

RefSeq

NP_079472.1

OpenTargets

ENSG00000109519

GeneCards

Q9HAV7

HPA

ENSG00000109519-GRPEL1

Ensembl

ENSP00000264954, ENST00000264954, ENSG00000109519

PRO

Q9HAV7

Pharos - Targets

Q9HAV7

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	10
UniProt:O15160 POLR1C	2	POLR1C [nucleoplasm] (R-HSA-63498) POLR1C [cytosol] (R-HSA-1964454)	0.601	4
UniProt:P38646 HSPA9	6	HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964)	0.564	2
UniProt:P07902 GALT	4	GALT Q188R [cytosol] (R-HSA-5610008) GALT K285N [cytosol] (R-HSA-5610009) GALT S135L [cytosol] (R-HSA-5610004) GALT [cytosol] (R-HSA-70356)	0.556	3