GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer

Stable Identifier
R-HSA-1250488
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Phosphorylated ERBB2:EGFR heterodimer recruits GRB2:SOS1 complex through phosphorylated tyrosine residues on either ERBB2 or EGFR that serve as direct docking sites for GRB2 (Xie et al. 1995).
Literature References
Participants
Input
Output
Participates
as an event of
Inferred From
Direct recruitment of GRB2:Sos1 to P-Erbb2mut dimer (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-04-21)
Cite Us!