TXNIP binds reduced thioredoxin

Stable Identifier
R-HSA-1250264
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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TXNIP binds reduced thioredoxin
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TXNIP interacts with the redox-active domain of thioredoxin (TRX) and is believed to act as an oxidative stress mediator by inhibiting TRX activity or by limiting its bioavailability (Nishiyama et al. 1999, Liyanage et al. 2007).
Literature References
PubMed ID Title Journal Year
17603038 Regulation of the bioavailability of thioredoxin in the lens by a specific thioredoxin-binding protein (TBP-2)

Liyanage, NP, Lou, MF, Fernando, MR

Exp Eye Res 2007
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Orthologous Events
TXNIP binds reduced thioredoxin (Bos taurus)
TXNIP binds reduced thioredoxin (Caenorhabditis elegans)
TXNIP binds reduced thioredoxin (Canis familiaris)
TXNIP binds reduced thioredoxin (Danio rerio)
TXNIP binds reduced thioredoxin (Drosophila melanogaster)
TXNIP binds reduced thioredoxin (Gallus gallus)
TXNIP binds reduced thioredoxin (Mus musculus)
TXNIP binds reduced thioredoxin (Rattus norvegicus)
TXNIP binds reduced thioredoxin (Saccharomyces cerevisiae)
TXNIP binds reduced thioredoxin (Schizosaccharomyces pombe)
TXNIP binds reduced thioredoxin (Sus scrofa)
Authored
Jupe, S  (2011-04-15)
Reviewed
Kufer, TA  (2011-04-28)
Rittinger, K  (2011-06-06)
Wong, E  (2011-06-06)
Created
Jupe, S  (2011-04-15)
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