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TXNIP is released from oxidized thioredoxin
Stable Identifier
R-HSA-1250253
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
TXNIP is released from oxidized thioredoxin (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
TXNIP is released from oxidized thioredoxin (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ROS induce the dissociation of TXNIP from thioredoxin, freeing TXNIP to subsequently bind NLRP3 and bring about activation of the NLRP3 inflammasome (Zhou et al. 2010).
Participants
Input
Oxidized thioredoxin:TXNIP [cytosol]
(Homo sapiens)
Output
2xHC-TXN [cytosol]
(Homo sapiens)
TXNIP [cytosol]
(Homo sapiens)
Participates
as an event of
Purinergic signaling in leishmaniasis infection (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
Inferred From
Txnip is released from oxidized thioredoxin (Mus musculus)
Authored
Jupe, S (2011-04-28)
Reviewed
Kufer, TA (2011-04-28)
Rittinger, K (2011-06-06)
Wong, E (2011-06-06)
Created
Jupe, S (2011-04-15)
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