Reactome | HIF1AN [cytosol]

HIF1AN [cytosol]

Stable Identifier

R-HSA-1234154

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

FIH1, HIF1AN (FIH1), Hypoxia-inducible factor 1-alpha inhibitor, HIF1N_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9NWT6 HIF1AN

Gene Names

HIF1AN, FIH1

Chain

initiator methionine:, chain:2-349

Reference Genes

BioGPS Gene:55662 HIF1AN

COSMIC (genes):HIF1AN HIF1AN

CTD Gene:55662 HIF1AN

dbSNP Gene:55662 HIF1AN

ENSEMBL:ENSG00000166135 HIF1AN

ENSEMBL_homo_sapiens_GENE:ENSG00000166135.14 HIF1AN

HGNC:17113 HIF1AN

KEGG Gene (Homo sapiens):55662 HIF1AN

Monarch:55662 HIF1AN

NCBI Gene:55662 HIF1AN

OMIM:606615 HIF1AN

UCSC:Q9NWT6 HIF1AN

Reference Transcript

RefSeq:NM_017902.2 HIF1AN

Other Identifiers

11721869_at

11721870_s_at

11721871_s_at

16708278

218525_3p_s_at

218525_PM_s_at

218525_s_at

226648_PM_at

226648_at

3260671

3260672

3260673

3260677

3260680

3260681

3260682

3260684

3260686

3260687

3260689

3260691

3260693

3260695

3260697

55662

59999_PM_at

59999_at

61379_at

65142_at

67441_at

73993_at

7929831

A_14_P117496

A_14_P118368

A_19_P00807243

A_23_P46964

A_32_P84640

GE55573

GE899817

GO:0003824

GO:0005112

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0008198

GO:0008270

GO:0016491

GO:0019826

GO:0023052

GO:0030154

GO:0031406

GO:0036139

GO:0036140

GO:0042803

GO:0043226

GO:0043433

GO:0045663

GO:0045746

GO:0046872

GO:0048471

GO:0048856

GO:0051059

GO:0051213

GO:0062101

GO:0071532

GO:0140096

GO:0140299

GO:2001214

HMNXSV003015725

Hs.119451.0.A1_3p_at

ILMN_1681812

PH_hs_0001380

TC10000724.hg

g8923568_3p_a_at

g8923568_3p_s_at

Participates

as a component of

FIH1:AscH-:Fe2+ [cytosol] (Homo sapiens)

Inferred To

HIF1AN [cytosol] (Bos taurus)

HIF1AN [cytosol] (Canis familiaris)

HIF1AN [cytosol] (Danio rerio)

HIF1AN [cytosol] (Gallus gallus)

HIF1AN [cytosol] (Mus musculus)

HIF1AN [cytosol] (Sus scrofa)

hif1an [cytosol] (Xenopus tropicalis)

Hif1an [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_060372.2

OpenTargets

ENSG00000166135

GeneCards

Q9NWT6

HPA

ENSG00000166135-HIF1AN

ZINC target

Q9NWT6

Ensembl

ENSG00000166135, ENSP00000299163, ENST00000299163

PRO

Q9NWT6

Pharos - Targets

Q9NWT6

Orphanet

24597

HMDB Protein

HMDBP01023

PDB

3KCX, 5OP6, 6HL5, 1H2M, 5OP8, 1H2N, 3D8C, 2CGO, 3P3N, 1MZE, 6HC8, 5JWK, 2YC0, 7A1Q, 7A1P, 1MZF, 2XUM, 6HKP, 2YDE, 1H2K, 1YCI, 4Z1V, 1H2L, 4NR1, 3OD4, 2CGN, 1IZ3, 4AI8, 7A1J, 7A1K, 6RUJ, 3KCY, 7A1M, 7A1L, 5OPC, 6HL6, 3P3P, 5JWL, 7A1N, 4Z2W, 7A1O, 2WA3, 6HA6, 2WA4, 4BIO, 2W0X, 6H9J, 7A1S, 4B7E, 2Y0I, 5JWP, 2ILM, 4JAA, 4B7K

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16665 HIF1A	7	HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.922	12
UniProt:Q05823 RNASEL	2	RNASEL [mitochondrial matrix] (R-HSA-5223312) RNASEL [cytosol] (R-HSA-1015684)	0.788	5
UniProt:P19838 NFKB1	8	NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.744	7
UniProt:P25963 NFKBIA	9	PolyUb-NFKBIA [cytosol] (R-HSA-6782960) NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805)	0.734	6
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.59	2
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.527	2
UniProt:O60547 GMDS	1	GMDS [cytosol] (R-HSA-6787620)	0.527	2
UniProt:Q9UM47 NOTCH3	20	Ub-NICD3 [cytosol] (R-HSA-9021546) Ub-NEXT3 [plasma membrane] (R-HSA-9021545) p-Y-NICD3 [cytosol] (R-HSA-9018581) Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911429) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911419) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911504) FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane] (R-HSA-1911517) FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane] (R-HSA-1911522) NOTCH3(40-1628) [extracellular region] (R-HSA-157639) NOTCH3(1629-1661) [plasma membrane] (R-HSA-157657) NEXT3 [plasma membrane] (R-HSA-157203) NICD3 [cytosol] (R-HSA-157647) NICD3 [nucleoplasm] (R-HSA-157928) Pre-NOTCH3 [endoplasmic reticulum membrane] (R-HSA-157102) 10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] (R-HSA-1467382) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] (R-HSA-1467307) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane] (R-HSA-1472871) NOTCH3(1572-2321) [plasma membrane] (R-HSA-157231) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region] (R-HSA-1983675) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane] (R-HSA-1983672)	0.527	2
UniProt:Q00653 NFKB2	6	monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol] (R-HSA-4755500) NFKB2(1-900) [cytosol] (R-HSA-2677931) K48-polyUb-p-7S-p100 [cytosol] (R-HSA-5607636) p-7S-p100 [cytosol] (R-HSA-5607629) NFKB2(1-454) [cytosol] (R-HSA-168144) NFKB2(1-454) [nucleoplasm] (R-HSA-177674)	0.527	2
UniProt:Q9BZF9 UACA	1	UACA [cytosol] (R-HSA-6804636)	0.508	2

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