Recruitment of HDAC1 by p107 (RBL1)

Stable Identifier
R-HSA-1227671
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
HDAC1 + p107(RBL1):E2F4:DP1 => HDAC1-p107(RBL2):E2F4:DP1
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
p107 (RBL1) in complex with E2F4 and DP1 or DP2 recruits histone deacetylase HDAC1 (possibly in complex with other chromatin modification proteins) through LXCXE-like motif, shared by pocket proteins, to repress transcription of E2F target genes in early G1.
Literature References
PubMed ID Title Journal Year
9724731 The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase

Robin, P, Harel-Bellan, A, Magnaghi-Jaulin, L, Trouche, D, Ferreira, R

Proc Natl Acad Sci U S A 1998
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!