Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex

Stable Identifier
R-HSA-1225961
Type
Reaction
Species
Homo sapiens
Compartment
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Recruitment of GRB2:SOS1 complex by SHC1 bound to phosphorylated dimers of EGFR cancer mutants has not been directly tested, but is assumed to happen in the same way it happens with the SHC1 bound to the phosphorylated homodimer of wild-type EGFR.

Literature References
PubMed ID Title Journal Year
8493579 Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

Chardin, P, Camonis, JH, Gale, NW, Van Aelst, L, Schlessinger, J, Wigler, MH, Bar-Sagi, D

Science 1993
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created