Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane]

Stable Identifier
R-HSA-1182967
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
plasma membrane
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Literature References
PubMed ID Title Journal Year
18227510 The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

Meyerson, M, Woo, MS, Mengwasser, KE, Toms, AV, Greulich, H, Wong, KK, Eck, MJ, Yun, CH

Proc Natl Acad Sci U S A 2008
17085664 Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors

Ladanyi, M, Chiang, A, Zakowski, MF, Miller, VA, Gong, Y, Kris, MG, Ouerfelli, O, Somwar, R, Li, AR, Balak, MN, Pao, W, Riely, GJ, Yang, G

Clin Cancer Res 2006
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candidates
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as a member of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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