Reactome | ISGylation of host protein filamin B

ISGylation of host protein filamin B

Stable Identifier

R-HSA-1169398

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ISG15 negatively regulates the scaffold protein filamin B. In response to type I IFNs, filamin B recruits RAC1, MEKK1, and MKK4, enhancing their sequential activation and thereby promoting JNK activation and apoptosis. ISGylation of filamin B leads to the disassociation of RAC1, MEKK1, and MKK4 from the scaffold, preventing type I IFN dependent JNK activation and apoptosis. It has been suggested that this inhibition of apoptosis may protect uninfected bystander cells from IFN-mediated apoptosis (Jeon et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
16009940	Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways Denison, C, Krug, RM, Huibregtse, JM, Gygi, S, Zhao, C	Proc Natl Acad Sci U S A	2005
19270716	ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway Yu, KR, Zhang, DE, Choi, JS, Bang, OS, Kim, KI, Oh, KH, Kim, SM, Lee, JY, Jeon, YJ, Ka, SH, Chung, CH	EMBO Rep	2009
12582176	High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction Malakhova, OA, Malakhov, MP, Zhang, DE, Jacobs, BS, Borden, EC, Kim, KI	J Biol Chem	2003