ISGylation of host protein filamin B

Stable Identifier
R-HSA-1169398
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ISG15 negatively regulates the scaffold protein filamin B. In response to type I IFNs, filamin B recruits RAC1, MEKK1, and MKK4, enhancing their sequential activation and thereby promoting JNK activation and apoptosis. ISGylation of filamin B leads to the disassociation of RAC1, MEKK1, and MKK4 from the scaffold, preventing type I IFN dependent JNK activation and apoptosis. It has been suggested that this inhibition of apoptosis may protect uninfected bystander cells from IFN-mediated apoptosis (Jeon et al, 2009).

Literature References
PubMed ID Title Journal Year
19270716 ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway

Jeon, YJ, Choi, JS, Lee, JY, Yu, KR, Kim, SM, Ka, SH, Oh, KH, Kim, KI, Zhang, DE, Bang, OS, Chung, CH

EMBO Rep 2009
16009940 Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways

Zhao, C, Denison, C, Huibregtse, JM, Gygi, S, Krug, RM

Proc Natl Acad Sci U S A 2005
12582176 High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction

Malakhov, MP, Kim, KI, Malakhova, OA, Jacobs, BS, Borden, EC, Zhang, DE

J Biol Chem 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created