SHP1 (PTPN6) binds JAK2 in the receptor complex

Stable Identifier
R-HSA-1168839
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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SHP1 (PTPN6) binds JAK2 in the receptor complex
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SHP1 binds GH-activated JAK2 and controls the duration of GH-dependent JAK2 phosphorylation in the liver, consequently hepatic GH signaling is prolonged in mice lacking SHP1 (Hackett et al. 1999).
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Inferred From
Shp1 binds Jak2 in the receptor complex (Mus musculus)
Authored
Jupe, S  (2010-10-14)
Reviewed
Herington, AC  (2011-06-13)
Waters, MJ  (2011-06-23)
Created
Jupe, S  (2011-01-10)
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