Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
p-S157,S161-NFKBIE [cytosol]
Stable Identifier
R-HSA-1168561
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S157,161-IKBE, Phospho-NF-kappa-B inhibitor epsilon, NFKBIE, IKBE_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
Activated IKK phosphorylates I-kappaB (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
NF-kappaB p65:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
NF-kappaB p65:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
NF-kappaB p65:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
SCF-beta-TrCP ubiquitinylates IkB (Homo sapiens)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
NF-kappaB p65:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S157,S161-NFKBIE [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00221 NFKBIE
Gene Names
NFKBIE, IKBE
Chain
chain:1-500
Reference Genes
BioGPS Gene:4794 NFKBIE
COSMIC (genes):NFKBIE NFKBIE
CTD Gene:4794 NFKBIE
dbSNP Gene:4794 NFKBIE
ENSEMBL:ENSG00000146232 NFKBIE
HGNC:7799 NFKBIE
KEGG Gene (Homo sapiens):4794 NFKBIE
Monarch:4794 NFKBIE
NCBI Gene:4794 NFKBIE
OMIM:604548 NFKBIE
UCSC:O00221 NFKBIE
Reference Transcript
RefSeq:NM_004556.2 NFKBIE
Other Identifiers
0002230722
10272
11743007_at
17019565
203927_at
2692
2955074
2955075
2955077
2955078
2955079
2955080
2955081
2955082
2955084
2955085
2955086
2955088
2955090
2955091
2955092
2955093
38276_at
4794
53701_at
5941
7896696
7896713
8126666
A0A024RD24
A_23_P30655
AAC51216
AL139392
CAB010272
CCDS34463
CH471081
EAX04262
EAX04263
ENSG00000146232
ENSP00000275015
ENST00000275015
ENST00000275015.9
EntrezGene:4794
EntrezGene:NFKBIE
g4758805_3p_at
GE81408
GO:0001650
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005730
GO:0005737
GO:0005794
GO:0005829
GO:0006810
GO:0008150
GO:0009058
GO:0034641
GO:0042942
GO:0042994
GO:0043226
GO:0048471
H0Y4W4
H3BNC2
HGNC:7799
HPA002692
HPA005941
ILMN_1717313
IPR002110
IPR020683
IPR036770
MIM:604548
NFKBIE
NFKBIE-201
NM_004556
NP_004547
PF12796
PH_hs_0026336
PR01415
Q7LC14
SM00248
TC06001762.hg
U91616
U91616_at
UPI000013DA3C
Participant Of
hasMember
p-IKB alpha,beta,epsilon [cytosol]
Other forms of this molecule
NFKBIE [cytosol]
p-S157,S161-Ub-NFKBIE [cytosol]
Inferred To
phospho-p-S157,S161-NFKBIE [cytosol] (Bos taurus)
phospho-p-S157,S161-NFKBIE [cytosol] (Canis familiaris)
phospho-p-S157,S161-NFKBIE [cytosol] (Danio rerio)
phospho-p-S157,S161-NFKBIE [cytosol] (Drosophila melanogaster)
phospho-p-S157,S161-NFKBIE [cytosol] (Gallus gallus)
phospho-p-S157,S161-NFKBIE [cytosol] (Mus musculus)
phospho-p-S157,S161-NFKBIE [cytosol] (Rattus norvegicus)
phospho-p-S157,S161-NFKBIE [cytosol] (Sus scrofa)
phospho-p-S157,S161-NFKBIE [cytosol] (Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 157
Coordinate
157
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 161
Coordinate
161
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_004547.2
OpenTargets
ENSG00000146232
GeneCards
O00221
PRO
O00221
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q01201 RELB
2
RELB [cytosol]
(R-HSA-5607652)
RELB [nucleoplasm]
(R-HSA-5607656)
0.564
2
UniProt:Q04206 RELA
6
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
SUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
0.488
2
© 2019
Reactome