Reactome | GP6 [plasma membrane]

GP6 [plasma membrane]

Stable Identifier

R-HSA-114574

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Platelet Glycoprotein VI

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Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Cell surface interactions at the vascular wall (Homo sapiens)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
      - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
      - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
- Platelet Adhesion to exposed collagen (Homo sapiens)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
      - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
      - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
  - GPVI binds Fyn and Lyn (Homo sapiens)
    - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
      - GP6 [plasma membrane] (Homo sapiens)
    - GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
      - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
  - Interaction of GPVI and FceRI gamma (Homo sapiens)
    - GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
      - GP6 [plasma membrane] (Homo sapiens)
    - GP6 [plasma membrane] (Homo sapiens)
- Platelet activation, signaling and aggregation (Homo sapiens)
  - GPVI-mediated activation cascade (Homo sapiens)
    - Binding of Syk tyrosine kinase (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Homo sapiens)
      - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : FceRI gamma dimer [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - GPVI stimulates PI3K beta, gamma (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - SYK autophosphorylates (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
    - p-Y348-SYK dissociates (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Homo sapiens)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Homo sapiens)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Homo sapiens)
        
        GP6 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HCN6 GP6

Gene Names

GP6

Chain

signal peptide:1-20, chain:21-339

Reference Genes

BioGPS Gene:51206 GP6

COSMIC (genes):GP6 GP6

CTD Gene:51206 GP6

dbSNP Gene:51206 GP6

ENSEMBL:ENSG00000088053 GP6

ENSEMBL_homo_sapiens_GENE:ENSG00000088053.11 GP6

ENSEMBL_homo_sapiens_GENE:ENSG00000274050.4 GP6

ENSEMBL_homo_sapiens_GENE:ENSG00000274566.4 GP6

ENSEMBL_homo_sapiens_GENE:ENSG00000275633.4 GP6

ENSEMBL_homo_sapiens_GENE:ENSG00000275931.4 GP6

ENSEMBL_homo_sapiens_GENE:ENSG00000276065.4 GP6

ENSEMBL_homo_sapiens_GENE:ENSG00000276211.4 GP6

ENSEMBL_homo_sapiens_GENE:ENSG00000277439.4 GP6

ENSEMBL_homo_sapiens_GENE:ENSG00000278316.4 GP6

ENSEMBL_homo_sapiens_GENE:ENSG00000278670.4 GP6

HGNC:14388 GP6

KEGG Gene (Homo sapiens):51206 GP6

Monarch:51206 GP6

NCBI Gene:51206 GP6

OMIM:605546 GP6

UCSC:Q9HCN6 GP6

Reference Transcript

Other Identifiers

11734187_a_at

11734188_x_at

16875549

220336_PM_s_at

220336_s_at

3870991

3870992

3870993

3870994

3870995

3870996

3870998

3870999

3871000

3871001

3871002

3871004

3871005

51206

8039294

A_23_P27784

A_33_P3461416

GO:0004888

GO:0005515

GO:0005518

GO:0005576

GO:0005615

GO:0005886

GO:0007155

GO:0007167

GO:0007596

GO:0007599

GO:0009986

GO:0016020

GO:0023052

GO:0030168

GO:0038023

GO:0038065

GO:0042060

GO:0043226

GO:0045121

GO:0060089

GO:0070062

GO:0097197

GO:1901731

GO:1990782

HMNXSV003000526

ILMN_1732269

ILMN_2223772

PH_hs_0029558

TC19002721.hg

g9955913_3p_a_at

Participates

as an input of

Interaction of GPVI and FceRI gamma (Homo sapiens)

as a component of

Inferred To

GP6 [plasma membrane] (Bos taurus)

GP6 [plasma membrane] (Canis familiaris)

GP6 [plasma membrane] (Sus scrofa)

GP6 [plasma membrane] (Xenopus tropicalis)

Gp6 [plasma membrane] (Mus musculus)

Gp6 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001242946.2, NP_001077368.2, NP_057447.5

OpenTargets

ENSG00000088053

GeneCards

Q9HCN6

HPA

ENSG00000088053-GP6

Ensembl

ENSP00000479873, ENSP00000478025, ENSG00000278316, ENSP00000482601, ENSG00000088053, ENSP00000481075, ENSG00000275633, ENSP00000479668, ENSP00000478709, ENSP00000480178, ENST00000333884, ENSP00000481583, ENST00000613801, ENST00000612184, ENST00000616456, ENSP00000484029, ENSP00000394922, ENSP00000479975, ENSG00000276065, ENSP00000481125, ENST00000622279, ENST00000612862, ENSG00000275931, ENSP00000481524, ENST00000610746, ENSG00000276211, ENSP00000478674, ENSP00000479513, ENST00000621278, ENST00000615407, ENSP00000483314, ENSP00000478918, ENST00000619136, ENST00000417454, ENST00000622653, ENSP00000308782, ENSP00000334552, ENSG00000274050, ENSP00000479034, ENST00000611436, ENST00000622589, ENST00000617954, ENST00000612096, ENST00000616319, ENST00000613649, ENSG00000278670, ENSP00000483612, ENST00000310373, ENSP00000480243, ENST00000614662, ENST00000610596, ENSG00000277439, ENSG00000274566, ENST00000614889

PRO

Q9HCN6

Pharos - Targets

Q9HCN6

Orphanet

18999

PDB

2GI7, 7R58, 5OU7, 7NMU, 5OU9, 5OU8

HMDB Protein

HMDBP13518

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875)	0.641	5
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.564	2
UniProt:P0DP25 CALM			0.524	2