Protein Kinase C, conventional [cytosol]

Stable Identifier
R-HSA-114528
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
These PKC isoforms are activated by PS in a Ca2+-dependent manner; they also bind DAG, which both increases the specificity of the enzyme for PS and also shifts the affinity for Ca2+ into the physiological range. They are targets of the tumour-promoting phorbol ester PMA, which activates these enzymes by eliminating the requirement for DAG and decreasing the concentration of Ca2+ needed for activation.
Participants
members
Participates
as an input of
Inferred To
Protein Kinase C, conventional [cytosol] (Caenorhabditis elegans)
Protein Kinase C, conventional [cytosol] (Canis familiaris)
Protein Kinase C, conventional [cytosol] (Dictyostelium discoideum)
Protein Kinase C, conventional [cytosol] (Drosophila melanogaster)
Protein Kinase C, conventional [cytosol] (Gallus gallus)
Protein Kinase C, conventional [cytosol] (Mus musculus)
Protein Kinase C, conventional [cytosol] (Rattus norvegicus)
Protein Kinase C, conventional [cytosol] (Saccharomyces cerevisiae)
Protein Kinase C, conventional [cytosol] (Schizosaccharomyces pombe)
Protein Kinase C, conventional [cytosol] (Sus scrofa)
Protein Kinase C, conventional [cytosol] (Xenopus tropicalis)
PRKCB [cytosol] (Bos taurus)
PRKCB [cytosol] (Danio rerio)
Cite Us!