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Oligomerization of BAX at the mitochondrial membrane
Stable Identifier
R-HSA-114275
Type
Reaction [binding]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation, translocation and oligomerization of BAX (Homo sapiens)
Oligomerization of BAX at the mitochondrial membrane (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Once integrated in the outer mitochondrial membrane, BAX forms oligomeric complexes which play an important role in cytochrome C release (Antonsson et al. 2001)
Literature References
PubMed ID
Title
Journal
Year
11136736
Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells.
Martinou, JC
,
Antonsson, B
,
Montessuit, S
,
Sanchez, B
J Biol Chem
2001
Participants
Input
x 2
BAX [mitochondrial outer membrane]
(Homo sapiens)
Output
Activated BAX [mitochondrial outer membrane]
(Homo sapiens)
Participates
as an event of
Activation, translocation and oligomerization of BAX (Homo sapiens)
Orthologous Events
Oligomerization of BAX at the mitochondrial membrane (Bos taurus)
Oligomerization of BAX at the mitochondrial membrane (Canis familiaris)
Oligomerization of BAX at the mitochondrial membrane (Danio rerio)
Oligomerization of BAX at the mitochondrial membrane (Mus musculus)
Oligomerization of BAX at the mitochondrial membrane (Rattus norvegicus)
Oligomerization of BAX at the mitochondrial membrane (Sus scrofa)
Created
Hardwick, JM (2004-08-09)
Tsujimoto, Y (2004-08-09)
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