Reactome | CCND1 [nucleoplasm]

CCND1 [nucleoplasm]

Stable Identifier

R-HSA-113832

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

G1/S-specific cyclin D1, PRAD1 oncogene, BCL-1 oncogene

Locations in the PathwayBrowser for interactor UniProt:P30260 CDC27

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External Reference Information

External Reference

UniProt:P24385 CCND1

Gene Names

CCND1, BCL1, PRAD1

Chain

chain:1-295

Reference Genes

BioGPS Gene:595 CCND1

COSMIC (genes):CCND1 CCND1

CTD Gene:595 CCND1

dbSNP Gene:595 CCND1

ENSEMBL:ENSG00000110092 CCND1

HGNC:1582 CCND1

KEGG Gene (Homo sapiens):595 CCND1

Monarch:595 CCND1

NCBI Gene:595 CCND1

OMIM:168461 CCND1

Reference Transcript

RefSeq:NM_053056.2 CCND1

Other Identifiers

0004010400

11721255_at

11721256_a_at

11721257_at

11751330_a_at

16728261

2017_s_at

2020_at

208711_s_at

208712_3p_at

208712_at

27802

2W96

2W99

2W9F

2W9Z

3338194

3338195

3338196

3338204

3338205

3338207

3338211

3338212

3338213

3338214

3338215

3338216

38418_at

595

5VZU

7942123

A_14_P117958

A_23_P202837

A_24_P124550

A_24_P193011

AAA36481

AAA52136

AAA58392

AAH00076

AAH01501

AAH14078

AAH23620

AAH25302

AAM34300

AAV38647

AAV38648

AF511593

AK313136

BAG35955

BC000076

BC001501

BC014078

BC023620

BC025302

BT019844

BT019845

CAA42470

CAA80558

CAB000024

CAG38775

CAG46896

CCDS8191

CCND1

CCND1-201

CH471076

CR536538

CR542099

EAW74748

ENSG00000110092

ENSP00000227507

ENST00000227507

ENST00000227507.2

EntrezGene:595

EntrezGene:CCND1

F5H437

g12652656_3p_s_at

g179364_3p_at

g179364_3p_x_at

GO:0000003

GO:0000079

GO:0000082

GO:0000122

GO:0000278

GO:0000307

GO:0000320

GO:0001889

GO:0001934

GO:0003674

GO:0003714

GO:0004672

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005654

GO:0005737

GO:0005829

GO:0005923

GO:0006367

GO:0006464

GO:0006468

GO:0006810

GO:0006950

GO:0006974

GO:0007049

GO:0007165

GO:0007267

GO:0007595

GO:0008134

GO:0008150

GO:0008283

GO:0008284

GO:0009058

GO:0010033

GO:0010039

GO:0010165

GO:0010243

GO:0010971

GO:0014070

GO:0016020

GO:0016055

GO:0016301

GO:0016538

GO:0017053

GO:0019221

GO:0019899

GO:0019901

GO:0030154

GO:0030234

GO:0030857

GO:0030968

GO:0031100

GO:0031571

GO:0031965

GO:0032026

GO:0032355

GO:0032991

GO:0033197

GO:0033327

GO:0033598

GO:0033601

GO:0034641

GO:0042493

GO:0042826

GO:0043226

GO:0043627

GO:0044321

GO:0044772

GO:0044877

GO:0045444

GO:0045471

GO:0045737

GO:0045787

GO:0048545

GO:0048856

GO:0050679

GO:0051301

GO:0051384

GO:0051412

GO:0051592

GO:0051726

GO:0060749

GO:0070064

GO:0070141

GO:0071157

GO:0071310

GO:0097421

GO:1900087

GO:2000045

HGNC:1582

HPA027802

ILMN_1688480

IPR004367

IPR006671

IPR013763

IPR015451

IPR036915

IPR039361

L09054

LRG_990

LRG_990t1

M64349

M73554

M74092

MIM:168461

MIM:193300

MIM:254500

NM_053056

NP_444284

PF00134

PF02984

PH_hs_0024184

Q6FI00

SM00385

SM01332

TC11000718.hg

UPI0000001285

X59798

X59798_at

Z23022

Participant Of

hasMember

hasComponent

input

CCND1 binds RUNX3 and displaces EP300

hasCandidate

CCND3,(CCND1,CCND2) [nucleoplasm]

Other forms of this molecule

p-T286-CCND1 [nucleoplasm]

p-T286-CCND1 [cytosol]

CCND1 [cytosol]

Inferred To

Ccnd1 [nucleoplasm] (Mus musculus)

Ghost homologue of CCND1 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of CCND1 [nucleoplasm] (Canis familiaris)

Ghost homologue of CCND1 [nucleoplasm] (Gallus gallus)

CCND1 [nucleoplasm] (Bos taurus)

CCND1 [nucleoplasm] (Danio rerio)

CCND1 [nucleoplasm] (Drosophila melanogaster)

CCND1 [nucleoplasm] (Rattus norvegicus)

CCND1 [nucleoplasm] (Sus scrofa)

CCND1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_444284.1

OpenTargets

ENSG00000110092

GeneCards

P24385

PRO

P24385

Orphanet

15408

HMDB Protein

HMDBP02156

PDB

2W99, 5VZU, 2W9Z, 2W96, 2W9F

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11802 CDK4	3	CDK4 [nucleoplasm] (R-HSA-113843) p-T172-CDK4 [nucleoplasm] (R-HSA-113830) CDK4 [cytosol] (R-HSA-68330)	0.979	33
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.952	18
UniProt:P46527 CDKN1B	8	p-T157-CDKN1B [cytosol] (R-HSA-198629) CDKN1B [cytosol] (R-HSA-198622) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.758	4
IntAct:EBI-4399559 UBIQ			0.743	4
UniProt:P24941 CDK2	5	CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.738	4
UniProt:Q00534 CDK6	3	CDK6 [nucleoplasm] (R-HSA-141283) CDK6 [cytosol] (R-HSA-68336) p-T177-CDK6 [nucleoplasm] (R-HSA-69628)	0.734	4
UniProt:Q96PU4 UHRF2	1	UHRF2 [nucleoplasm] (R-HSA-976050)	0.602	4
UniProt:Q5XUX0 FBXO31	1	FBXO31 [cytosol] (R-HSA-8850911)	0.576	4
UniProt:Q96TE0 Q96TE0			0.556	3
UniProt:P10275 AR	4	SUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984) AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174)	0.544	4
UniProt:O15379 HDAC3	2	Unfolded HDAC3 [cytosol] (R-HSA-6813777) HDAC3 [nucleoplasm] (R-HSA-442464)	0.544	3
UniProt:P06493 CDK1	10	CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) CDK1 [cytosol] (R-HSA-170075) p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T14-CDK1 [nucleoplasm] (R-HSA-170045)	0.527	2
UniProt:Q16656 NRF1	1	NRF1 [nucleoplasm] (R-HSA-1592205)	0.508	2
UniProt:P30260 CDC27	2	CDC27 [cytosol] (R-HSA-174073) CDC27 [nucleoplasm] (R-HSA-174175)	0.499	3
UniProt:P42771 CDKN2A	80	p16INK4A E88* [cytosol] (R-HSA-9632588) p16INK4A D84G [cytosol] (R-HSA-9632461) p16INK4A R87P [cytosol] (R-HSA-9632335) p16INK4A V126D [cytosol] (R-HSA-9631055) p16INK4A W110* [cytosol] (R-HSA-9632585) p16INK4A D84H [cytosol] (R-HSA-9632489) p16INK4A R80* [cytosol] (R-HSA-9632586) p16INK4A P114L [cytosol] (R-HSA-9630916) p16INK4A R58* [cytosol] (R-HSA-9632582) p16INK4A D84N [cytosol] (R-HSA-9632483) p16INK4A M53I [cytosol] (R-HSA-9630911) p16INK4A D84Y [cytosol] (R-HSA-9632478) p16INK4A G101W [cytosol] (R-HSA-9631257) p16INK4A P81L [cytosol] (R-HSA-9632280) p16INK4A A20P [cytosol] (R-HSA-9630805) p16INK4A D84V [cytosol] (R-HSA-9632465) p16INK4A P81T [cytosol] (R-HSA-9632275) p16INK4A P81H [cytosol] (R-HSA-9632293) p16INK4A D84A [cytosol] (R-HSA-9632486) p16INK4A P81R [cytosol] (R-HSA-9632294) p16INK4A E10* [cytosol] (R-HSA-9648382) p16INK4A S12* [cytosol] (R-HSA-9648383) p16INK4A P114T [cytosol] (R-HSA-9631034) p16INK4A P114S [cytosol] (R-HSA-9631027) p16INK4A G23fs3 [cytosol] (R-HSA-9648652) p16INK4A E61 [cytosol] (R-HSA-9648396) p16INK4A A20T [cytosol] (R-HSA-9630861) p16INK4A A36fs17 [cytosol] (R-HSA-9648653) p16INK4A E69 [cytosol] (R-HSA-9648397) p16INK4A W15fs1 [cytosol] (R-HSA-9648654) p16INK4A Y44 [cytosol] (R-HSA-9648398) p16INK4A T18fs15 [cytosol] (R-HSA-9648655) p16INK4A E26 [cytosol] (R-HSA-9648392) p16INK4A E33* [cytosol] (R-HSA-9648393) p16INK4A Q50* [cytosol] (R-HSA-9648394) p16INK4A E120* [cytosol] (R-HSA-9632587) p16INK4A S7fs8 [cytosol] (R-HSA-9648651) p16INK4A W15 [cytosol] (R-HSA-9648395) p16INK4A P75* [cytosol] (R-HSA-9648388) p16INK4A C72* [cytosol] (R-HSA-9648389) p16INK4A E119* [cytosol] (R-HSA-9648390) p16INK4A A20E [cytosol] (R-HSA-9630855) p16INK4A N39fs14 [cytosol] (R-HSA-9648647) p16INK4A P114R [cytosol] (R-HSA-9631046) p16INK4A P114H [cytosol] (R-HSA-9631043) p16INK4A E27 [cytosol] (R-HSA-9648387) p16INK4A P81S [cytosol] (R-HSA-9632287) p16INK4A G101V [cytosol] (R-HSA-9631263) p16INK4A Y44fs1 [cytosol] (R-HSA-9648664) p16INK4A V126I [cytosol] (R-HSA-9631130) p16INK4A L16fs9 [cytosol] (R-HSA-9648663) p16INK4A V126A [cytosol] (R-HSA-9631126) p16INK4A T18fs8 [cytosol] (R-HSA-9648656) p16INK4A V126F [cytosol] (R-HSA-9631120) p16INK4A L37fs16 [cytosol] (R-HSA-9648659) p16INK4A G35V [cytosol] (R-HSA-9631308) p16INK4A G23D [cytosol] (R-HSA-9630892) p16INK4A R24P [cytosol] (R-HSA-9630828) p16INK4A R80P [cytosol] (R-HSA-9632270) p16INK4A G35A [cytosol] (R-HSA-9631306) p16INK4A E88K [cytosol] (R-HSA-9632548) p16INK4A T77P [cytosol] (R-HSA-9632257) p16INK4A L97R [cytosol] (R-HSA-9632512) p16INK4A T18_A19dup [cytosol] (R-HSA-9632192) p16INK4A G67_N71del [cytosol] (R-HSA-9632252) p16INK4A A60R [cytosol] (R-HSA-9632216) p16INK4A D74Y [cytosol] (R-HSA-9632088) p16INK4A A60V [cytosol] (R-HSA-9632212) p16INK4A R112_L113insR [cytosol] (R-HSA-9632566) p16INK4A R99P [cytosol] (R-HSA-9632531) p16INK4A [cytosol] (R-HSA-182578) p16INK4A G35E [cytosol] (R-HSA-9631314) p16INK4A G35W [cytosol] (R-HSA-9631328) p16INK4A T77S [cytosol] (R-HSA-9632256) p16INK4A G35R [cytosol] (R-HSA-9631316) p16INK4A G23V [cytosol] (R-HSA-9631157) p16INK4A A60E [cytosol] (R-HSA-9632202) p16INK4A G23S [cytosol] (R-HSA-9631163) p16INK4A L97P [cytosol] (R-HSA-9632523) p16INK4A A60S [cytosol] (R-HSA-9632206)	0.491	2
UniProt:Q05086-3 UBE3A			0.488	2
UniProt:P38398 BRCA1	5	SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-5683800) BRCA1 [nucleoplasm] (R-HSA-50949) p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-75234)	0.463	3
UniProt:Q13761 RUNX3	7	p-Y-RUNX3 [cytosol] (R-HSA-8937805) PolyUb-RUNX3 [nucleoplasm] (R-HSA-8952417) PolyUb-K94,K148-RUNX3 [nucleoplasm] (R-HSA-8952387) PolyUb-K94,K148-RUNX3 [cytosol] (R-HSA-8952400) Ac-K94,K171-RUNX3 [nucleoplasm] (R-HSA-8951965) RUNX3 [cytosol] (R-HSA-8937797) RUNX3 [nucleoplasm] (R-HSA-8865393)	0.462	8