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POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template
Stable Identifier
R-HSA-110316
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Binding of Pol eta to lesioned DNA template
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
Translesion Synthesis by POLH (Homo sapiens)
POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
DNA polymerase eta (POLH) belongs to Y family of DNA polymerases. POLH binds PCNA monoubiquitinated at lysine K164 by the RAD18:UBE2B (RAD18:RAD6) or RBX1:CUL4:DDB1:DTL complexes in response to DNA damage. POLH C-terminus contains a conserved PCNA interaction motif, while the catalytic domain of POLH contains a conserved monoubiquitin binding motif. POLH is most efficient in recognition and repair of thymine-thymine cyclobutane pyrimidine dimers (TT-CPD) induced by UV-mediated DNA damage (Masutani et al. 2000, Kannouche et al. 2004)
Literature References
PubMed ID
Title
Journal
Year
10856253
Mechanisms of accurate translesion synthesis by human DNA polymerase eta.
Kusumoto, R
,
Iwai, S
,
Masutani, C
,
Hanaoka, F
EMBO J
2000
15149598
Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage
Kannouche, PL
,
Lehmann, AR
,
Wing, J
Mol. Cell
2004
Participants
Input
MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm]
(Homo sapiens)
POLH [nucleoplasm]
(Homo sapiens)
Output
POLH:MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Translesion Synthesis by POLH (Homo sapiens)
This event is regulated
Negatively by
Regulator
RCHY1 [nucleoplasm]
(Homo sapiens)
Orthologous Events
POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Bos taurus)
POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Caenorhabditis elegans)
POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Canis familiaris)
POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Danio rerio)
POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Drosophila melanogaster)
POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Gallus gallus)
POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Mus musculus)
POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Rattus norvegicus)
POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Saccharomyces cerevisiae)
POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Schizosaccharomyces pombe)
POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Sus scrofa)
POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Xenopus tropicalis)
Authored
Gopinathrao, G (2004-01-29)
Reviewed
Borowiec, JA (2015-01-07)
Created
Gopinathrao, G (2004-01-29)
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