Binding of Grb10 to the insulin receptor

Stable Identifier
R-HSA-110011
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Binding of Grb10 to the insulin receptor
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Grb10 negatively regulates the insulin-dependent phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor (Wick et al, 2003;Langlais et al, 2004).
Literature References
PubMed ID Title Journal Year
12493740 Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.

Shoelson, SE, Ramos, FJ, Dong, LQ, Werner, ED, Langlais, P, Wick, KR, Liu, F

J Biol Chem 2003
14615605 Negative regulation of insulin-stimulated mitogen-activated protein kinase signaling by Grb10.

Quon, MJ, Li, Y, Hu, D, Ramos, FJ, Dong, LQ, Langlais, P, Liu, F

Mol Endocrinol 2004
Participants
Input
Output
Participates
as an event of
Orthologous Events
Binding of Grb10 to the insulin receptor (Bos taurus)
Binding of Grb10 to the insulin receptor (Canis familiaris)
Binding of Grb10 to the insulin receptor (Danio rerio)
Binding of Grb10 to the insulin receptor (Gallus gallus)
Binding of Grb10 to the insulin receptor (Mus musculus)
Binding of Grb10 to the insulin receptor (Rattus norvegicus)
Binding of Grb10 to the insulin receptor (Sus scrofa)
Binding of Grb10 to the insulin receptor (Xenopus tropicalis)
Created
Charalambous, M  (2004-04-29)
Cite Us!