GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS

Stable Identifier
R-HSA-109807
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SOS promotes the formation of GTP-bound RAS, thus activating this protein. RAS activation results in activation of the protein kinases RAF1, B-Raf, and MAP-ERK kinase kinase (MEKK), and the catalytic subunit of PI3K, as well as of a series of RALGEFs. The activation cycle of RAS GTPases is regulated by their interaction with specific guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). GEFs promote activation by inducing the release of GDP, whereas GAPs inactivate RAS-like proteins by stimulating their intrinsic GTPase activity. NGF-induced RAS activation via SHC-GRB2-SOS is maximal at 2 min but it is no longer detected after 5 min. Therefore, the transient activation of RAS obtained through SHC-GRB2-SOS is insufficient for the prolonged activation of ERKs found in NGF-treated cells.
Literature References
PubMed ID Title Journal Year
9690470 The structural basis of the activation of Ras by Sos

Boriack-Sjodin, PA, Margarit, SM, Kuriyan, J, Bar-Sagi, D

Nature 1998
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of GRB2-1:SOS1:p-Y427-SHC1 [cytosol]

Inferred From
Authored
Reviewed
Created
Cite Us!