Reactome | KLHL25 [cytosol]

KLHL25 [cytosol]

Stable Identifier

R-GGA-8863189

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

KLHL25, E1BW35

Locations in the PathwayBrowser

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Immune System (Gallus gallus)

- Adaptive Immune System (Gallus gallus)
  - Class I MHC mediated antigen processing & presentation (Gallus gallus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Gallus gallus)
      - Interaction of E3 with substrate and E2-Ub complex (Gallus gallus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL25 [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL25 [cytosol] (Gallus gallus)
      - Polyubiquitination of substrate (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL25 [cytosol] (Gallus gallus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL25 [cytosol] (Gallus gallus)
        
        E3:Ub:substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL25 [cytosol] (Gallus gallus)
      - Release of E3 from polyubiquitinated substrate (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL25 [cytosol] (Gallus gallus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL25 [cytosol] (Gallus gallus)
      - Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL25 [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL25 [cytosol] (Gallus gallus)
        
        E3:Ub:substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL25 [cytosol] (Gallus gallus)

Metabolism of proteins (Gallus gallus)

- Post-translational protein modification (Gallus gallus)
  - Neddylation (Gallus gallus)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Gallus gallus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL25 [cytosol] (Gallus gallus)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL25 [cytosol] (Gallus gallus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Gallus gallus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Gallus gallus)
        
        CRL E3 ubiquitin ligases [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL25 [cytosol] (Gallus gallus)
      - CRL E3 ubiquitin ligases [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL25 [cytosol] (Gallus gallus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Gallus gallus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL25 [cytosol] (Gallus gallus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL25 [cytosol] (Gallus gallus)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Gallus gallus)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL25 [cytosol] (Gallus gallus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        RBX1:CUL3:BTB [cytosol] (Gallus gallus)
        
        BTB proteins [cytosol] (Gallus gallus)
        
        KLHL25 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:E1BW35

Gene Names

KLHL25

Reference Genes

BioGPS Gene:770701 KLHL25

ENSEMBL:ENSGALG00000006826

ENSEMBL:ENSGALG00010020390.1 KLHL25

KEGG Gene (Gallus gallus):770701 KLHL25

Monarch:770701 KLHL25

NCBI Gene:770701 KLHL25

Reference Transcript

Other Identifiers

770701

GO:0005515

GO:0005737

GO:0006511

GO:0030163

GO:0031463

GT_A_87_P006812

GT_A_87_P012229

GT_A_87_P033181

Gga.19351.1.S1_at

GgaAffx.4245.1.S1_at

Participates

as a member of

BTB proteins [cytosol] (Gallus gallus)

Inferred From

KLHL25 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_015147549.1, XP_015147548.1, XP_015147550.1

OpenTargets

ENSG00000183655

Ensembl

ENSGALT00010049281, ENSGALT00010049291, ENSGALT00010049282, ENSGALT00010049279, ENSGALG00010020390, ENSGALP00010029129, ENSGALP00010029130, ENSGALT00010049288, ENSGALP00010029128, ENSGALT00010049285, ENSGALP00010029136, ENSGALT00010049274, ENSGALP00010029125, ENSGALP00010029134, ENSGALP00010029133, ENSGALT00010049286, ENSGALP00010029138

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